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1. WO1996040684 - PROCESS FOR PREPARATION OF BIPHENYL DERIVATIVES

Publication Number WO/1996/040684
Publication Date 19.12.1996
International Application No. PCT/US1996/009117
International Filing Date 06.06.1996
Chapter 2 Demand Filed 24.12.1996
IPC
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Y02P 20/55
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
20Technologies relating to chemical industry
50Improvements relating to the production of products other than chlorine, adipic acid, caprolactam, or chlorodifluoromethane, e.g. bulk or fine chemicals or pharmaceuticals
55Synthetic design, e.g. reducing the use of auxiliary or protecting groups
Applicants
  • AMERICAN HOME PRODUCTS CORPORATION [US]/[US]
Inventors
  • GIGUERE, Pierre
  • IERA, Silvio
  • BERNATCHEZ, Michel
  • BARRECA, Giuseppe
  • CASTALDI, Graziano
  • CANNATA, Vincenzo
Agents
  • ALICE, Ronald, W.
  • WILEMAN, David, Francis
Priority Data
08/478,59207.06.1995US
08/657,49004.06.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PREPARATION OF BIPHENYL DERIVATIVES
(FR) PROCEDE DE PREPARATION DE DERIVES DE BIPHENYLE
Abstract
(EN)
A process is described for preparing a compound of formula (I), or a salt thereof; wherein X is a protecting group; and R1, R2, R3 and R4 are each independently hydrogen, C1-6alkyl or C1-6perfluoroalkyl; R5 is hydrogen or, when n is 1, R5 taken together with R3 comprises a double bond; m is 1, 2 or 3; n is 0 or 1; and p is 0, 1 or 2; by reacting a compound of formula (II) or a salt thereof; wherein R1 to R5, m, n and p are each as defined above and R6 is chloro, bromo, or iodo; with a compound of formula (III) or a salt thereof; wherein X is a protecting group and R7 is a zinc or tin moiety (such as ZnCl, ZnBr or Sn(C1-6alkyl)3); in the presence of a palladium or nickel catalyst.
(FR)
L'invention concerne un procédé permettant de préparer un composé de la formule (I), où un sel de celui-ci, formule dans laquelle: X représente un groupe protecteur; R1, R2, R3 et R4 représentent indépendamment hydrogène, alkyle C1-C6 ou perfluoroalkyle C1-C6; R5 représente hydrogène ou, lorsque n vaut 1, R5 comprend avec R3 une liaison double; m vaut 1, 2 ou 3; n vaut 0 ou 1; et p vaut 0, 1 ou 2. Ledit procédé consiste à faire réagir un composé de la formule (II), ou un sel de celui-ci, formule dans laquelle les groupes R1 à R5, m, n et p correspondent à la définition donnée ci-dessus et R6 est un groupe chloro, bromo ou iodo, avec un composé de la formule (III), ou un sel de celui-ci, formule dans laquelle X représente un groupe protecteur et R7 représente une fraction zinc ou étain (telle que ZnCl, ZnBr ou Sn(alkyle C1-C6)3), en présence d'un catalyseur au palladium ou au nickel.
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