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1. WO1996040627 - THIOCATIONIC LIPIDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF

Publication Number WO/1996/040627
Publication Date 19.12.1996
International Application No. PCT/US1996/007121
International Filing Date 17.05.1996
Chapter 2 Demand Filed 30.12.1996
IPC
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
C07C 381/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
381Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/-C07C337/142
12Sulfonium compounds
C12N 15/88 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
88using microencapsulation, e.g. using liposome vesicle
CPC
A61K 47/543
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
543Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
A61K 9/1272
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
1272with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
C07C 381/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
381Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
12Sulfonium compounds
C12N 15/88
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
88using microencapsulation, e.g. using ; amphiphile; liposome vesicle
Applicants
  • GEN-PROBE INCORPORATED [US]/[US]
Inventors
  • SRIDHAR, C., Nagaraja
  • DATTAGUPTA, Nanibhushan
  • PATEL, Jasmin, R.
  • DAS, Aditya, Ranjan
Agents
  • SCHNEIDER, Carol, A.
  • VIERING, JENTSCHURA & PARTNER
Priority Data
08/480,20307.06.1995US
08/480,20407.06.1995US
08/480,62207.06.1995US
08/482,30507.06.1995US
08/482,43007.06.1995US
08/482,49707.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THIOCATIONIC LIPIDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF
(FR) LIPIDES THIOCATIONIQUES, PREPARATIONS PHARMACEUTIQUES ET LEURS MODES D'UTILISATION
Abstract
(EN)
Lipid molecules bearing a cationic charge are described. These cationic lipids are useful in the delivery of biomolecules, such as oligonucleotides, nucleic acids, peptides, diagnostic imaging agents, proteins and drug molecules. In the form of liposomes, they can effectively be used for the intracellular delivery of biomolecules for therapeutic or diagnostic purposes.
(FR)
L'invention porte sur des molécules de lipides à charge cationique utiles pour libérer des biomolécules telles que des oligonucléotides, des acides nucléiques, des peptides, des agents de diagnostics par imagerie, des protéines et des molécules de médicaments. Sous la forme de liposomes, elles peuvent être utilisées efficacement pour assurer la libération intracellulaire de biomolécules à des fins thérapeutiques ou diagnostiques.
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