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1. WO1996040285 - NOVEL TARGETED COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC USE

Publication Number WO/1996/040285
Publication Date 19.12.1996
International Application No. PCT/US1996/009938
International Filing Date 06.06.1996
Chapter 2 Demand Filed 19.12.1996
IPC
A61K 49/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparations
CPC
A61K 49/0002
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
0002General or multifunctional contrast agents, e.g. chelated agents
A61K 49/223
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparation ; Optoacoustic imaging preparations
222characterised by a special physical form, e.g. emulsions, liposomes
223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
A61K 49/227
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparation ; Optoacoustic imaging preparations
222characterised by a special physical form, e.g. emulsions, liposomes
227Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
A61K 49/228
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparation ; Optoacoustic imaging preparations
222characterised by a special physical form, e.g. emulsions, liposomes
228Host-guest complexes, clathrates, chelates
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
B82Y 5/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Applicants
  • IMARx PHARMACEUTICAL CORP. [US]/[US] (AllExceptUS)
  • UNGER, Evan, C. [US]/[US] (UsOnly)
  • SHEN, Dekang [CN]/[US] (UsOnly)
  • WU, Guanli [CN]/[US] (UsOnly)
Inventors
  • UNGER, Evan, C.
  • SHEN, Dekang
  • WU, Guanli
Agents
  • MILLER, Suzanne, E.
Priority Data
08/497,68407.06.1995US
08/640,46401.05.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL TARGETED COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC USE
(FR) NOUVELLES COMPOSITIONS CIBLEES, DESTINEES A UNE UTILISATION DIAGNOSTIQUE ET THERAPEUTIQUE
Abstract
(EN)
Novel targeted compositions which may be used for diagnostic and therapeutic use. The compositions may comprise a lipid, a protein or a polymer and a gas, in combination with a targeting ligand. The targeting ligand targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The contrast media can be used in conjunction with diagnostic imaging, such as ultrasound, as well as therapeutic applications, such as therapeutic ultrasound.
(FR)
Ces nouvelles compositions ciblées, que l'on peut utiliser à des fins diagnostiques et thérapeutiques, peuvent comprendre un lipide, une protéine ou un polymère, ainsi qu'un gaz, en combinaison avec un ligand de ciblage. Ce ligand cible des tissus, des cellules ou des récepteurs, notamment des cellules myocardiques, endothéliales, épithéliales, tumorales, ainsi que le récepteur de la glycoprotéine GPIIbIIIa. On peut utiliser ces substances de contraste conjointement avec l'imagerie diagnostique, telle que l'échographie, ainsi qu'avec des applications thérapeutiques, telles que l'ultrasonothérapie.
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