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1. WO1996040284 - USE OF METHIONINASE IN ANTI-METHIONINE AND ANTI-HOMOCYSTEINE CHEMOTHERAPY

Publication Number WO/1996/040284
Publication Date 19.12.1996
International Application No. PCT/US1996/009935
International Filing Date 07.06.1996
Chapter 2 Demand Filed 20.11.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C12N 9/88 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
88Lyases (4.)
CPC
A61K 31/337
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
337having four-membered rings, e.g. taxol
A61K 38/51
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
51Lyases (4)
A61K 47/60
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
59obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
60the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
Applicants
  • ANTICANCER, INC. [US]/[US]
Inventors
  • TAN, Yuying
  • LISHKO, Valeryi
Agents
  • MILLMAN, Robert, A.
Priority Data
08/486,51907.06.1995US
08/624,54103.05.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF METHIONINASE IN ANTI-METHIONINE AND ANTI-HOMOCYSTEINE CHEMOTHERAPY
(FR) UTILISATION DE METHIONINASE EN CHIMIOTHERAPIE ANTI-METHIONINE ET ANTI-HOMOCYSTEINE
Abstract
(EN)
The invention provides highly pure, endotoxin free methioninase compositions that have been prepared from natural material and from a recombinant host. The invention further provides methioninase that has been coupled to a polymer such as polyethylene glycol. The isolation of a methioninase encoding nucleic acid molecule and the generation of high expression vectors containing the methioninase encoding nucleic acid molecule is also provided.
(FR)
L'invention concerne des compositions de méthioninase, de grande pureté, exemptes d'endotoxine, préparées à partir d'un matériau naturel et d'un hôte recombiné. L'invention concerne en outre de la méthioninase couplée à un polymère tel que du polyéthylèneglycol. L'invention concerne par ailleurs l'isolement d'une molécule d'acide nucléique codant la méthioninase et la production de vecteurs d'expression élevée contenant la molécule d'acide nucléique codant la méthioninase.
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