Processing

Please wait...

Settings

Settings

Goto Application

1. WO1996040275 - IMPROVEMENTS IN OR RELATING TO CONTRAST AGENTS

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

Claims

1. A diagnostic contrast agent comprising gas
microbubbles or a gas precursor stabilised by non-proteinaceous crosslinked or polymerised amphiphilic material characterised in that said amphiphilic material comprises a membrane-forming lipid crosslinked or polymerised in the hydrophilic portion thereof.

2. A contrast agent as claimed in claim 1 wherein said membrane-forming lipid comprises at least one
phospholipid.

3. A contrast agent as claimed in claim 2 wherein said phospholipid comprises one or more
diacylphosphatidylcholines , diacylphosphatidylserines , diacylphosphatidylglycerols , diacylphosphatidylethanol -amines and/or diacylphosphatidylinositols .

4. A contrast agent as claimed in claim 3 wherein said phospholipid comprises a blend of one or more
diacylphosphatidylserines with one or more
diacylphosphatidylcholines and/or diacylphosphatidic acids .

5. A contrast agent as claimed in any of claims 2 to 4 wherein said phospholipid comprises a
dialkanoylphosphatidylserine .

6. A contrast agent as claimed in any of the preceding claims wherein said amphiphilic material further comprises a sterol .

7. A contrast agent as claimed in any of the preceding claims wherein said amphiphilic material further comprises polyethylene glycol moieties.

8. A contrast agent as claimed in any of the preceding claims wherein said crosslinked or polymerised membrane-forming lipid is an oligomer containing 2-20 repeating units .

9. A contrast agent as claimed in any of the preceding claims comprising microbubbles of gas selected from air, nitrogen, oxygen, hydrogen, nitrous oxide, carbon dioxide, helium, argon, sulphur fluorides, optionally fluorinated low molecular weight hydrocarbons, and mixtures of any of the foregoing.

10. A contrast agent as claimed in claim 9 comprising microbubbles of sulphur hexafluoride and/or one or more perfluorinated low molecular weight hydrocarbons.

11. Use of a contrast agent as claimed in any of the preceding claims in diagnostic imaging.

12. Use of a contrast agent as claimed in any of claims 1 to 10 in diagnostic ultrasound imaging.

13. Use of a contrast agent as claimed in any of claims 1 to 10 in magnetic resonance imaging.

14. A method of generating enhanced images of a human or non-human animal body which comprises administering to said body a contrast agent as claimed in any of claims 1 to 10 and generating an ultrasound or magnetic resonance image of at least a part of said body.

15. A process for the preparation of a contrast agent as claimed in claim 1 which comprises forming an aqueous dispersion of vesicles comprising gas, a gas precursor or a volatile organic liquid stabilised by one or more membrane-forming lipids, crosslinking or polymerising at least part of said lipid or lipids in the hydrophilic portion thereof before, during or after such vesicle formation and, if necessary, removing the gas or liquid content of the vesicles and introducing a desired gas content .

16. A process as claimed in claim 15 wherein an aqueous dispersion of vesicles comprising a volatile halogenated hydrocarbon, sulphur hexafluoride or a perfluoroalkane gas or gas mixture is formed.

17. A process as claimed in claim 15 or claim 16 wherein the dispersion of crosslinked or polymerised vesicles is subsequently lyophilised.