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1. WO1996040231 - METHOD FOR OBTAINING RECEPTOR AGONIST ANTIBODIES

Publication Number WO/1996/040231
Publication Date 19.12.1996
International Application No. PCT/US1996/009613
International Filing Date 07.06.1996
Chapter 2 Demand Filed 21.11.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/71 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
71for growth factors; for growth regulators
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 7/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
06Antianaemics
C07K 14/71
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
71for growth factors; for growth regulators
C07K 16/2863
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2863against receptors for growth factors, growth regulators
Applicants
  • SMITHKLINE BEECHAM CORPORATION [US]/[US] (AllExceptUS)
  • YOUNG, Peter, Ronald [US]/[US] (UsOnly)
  • ERICKSON-MILLER, Connie, L. [US]/[US] (UsOnly)
Inventors
  • YOUNG, Peter, Ronald
  • ERICKSON-MILLER, Connie, L.
Agents
  • JERVIS, Herbert, H.
Priority Data
08/474,67307.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR OBTAINING RECEPTOR AGONIST ANTIBODIES
(FR) PROCEDE D'OBTENTION D'ANTICORPS ANTAGONISTES DE RECEPTEURS
Abstract
(EN)
A method is provided for generating antibodies which demonstrate the agonist properties of the naturally occuring ligand of a receptor molecule by using as an immunogen a recombinant immunogen which corresponds to a multimeric form of a receptor. In this immunogen the extracellular domains are in a similar disposition to that expected for receptors having two or more subunits on the surface of the cell.
(FR)
L'invention porte sur un procédé de production d'anticorps présentant les propriétés agonistes du ligand d'origine naturelle d'une molécule réceptrice en recourant comme immunogène à un immunogène de recombinaison correspondant à une forme multimère d'un récepteur. Dans cet immunogène les domaines extracellulaires sont dans une disposition similaire à celle qu'on attend de récepteurs présentant deux sous-unités à la surface de la cellule ou davantage.
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