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1. WO1996040205 - METABOLIC EFFECTS OF CERTAIN GLUTATHIONE ANALOGS

Publication Number WO/1996/040205
Publication Date 19.12.1996
International Application No. PCT/US1996/009057
International Filing Date 05.06.1996
Chapter 2 Demand Filed 20.11.1996
IPC
A61K 38/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
06Tripeptides
CPC
A61K 38/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
06Tripeptides
A61K 38/063
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
06Tripeptides
063Glutathione
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 7/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
A61P 7/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
04Antihaemorrhagics; Procoagulants; Haemostatatic agents; Antifibrinolytic agents
Applicants
  • TERRAPIN TECHNOLOGIES, INC. [US]/[US]
Inventors
  • KAUVAR, Lawrence, M.
  • LYTTLE, Matthew, H.
  • MORGAN, Amy, S.
  • BORCH, Richard, F.
Agents
  • MURASHIGE, Kate, H.
Priority Data
08/482,64507.06.1995US
08/636,51619.04.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METABOLIC EFFECTS OF CERTAIN GLUTATHIONE ANALOGS
(FR) EFFETS METABOLIQUES DE CERTAINS ANALOGUES DE GLUTATHIONE
Abstract
(EN)
Compounds of formula (1) and the esters, amides, amide/esters and salts thereof, wherein YCO is $g(g)-glu or $g(b)-asp; G* is phenylglycine or glycine; Z is CH2, O or S; and X is a hydrocarbon radical of 1-20C; are useful in modulating hematopoiesis in bone marrow, mitigating the bone-marrow-destructive effects of a chemotherapeutic agent, and in potentiating the toxicity of chemotherapeutic agents.
(FR)
Cette invention se rapporte à des composés représentés par la formule (1), ainsi qu'aux esters, amides, amides/esters et sels de ces composés. Dans cette formule YCO représente $g(g)-glu ou $g(b)-asp; G* représente phénylglycine ou glycine; Z représente CH2, O ou S; et X représente un radical hydrocarbure de 1 à 20C. Ces composés et leurs esters, amides et sels sont utiles pour moduler l'hématopoïèse dans la moëlle osseuse, pour attenuer les effets destructeurs sur la moëlle osseuse d'un agent chimiothérapeutique et pour potentialiser la toxicité d'agents chimiothérapeutiques.
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