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1. WO1996040204 - NOVEL INHIBITORS OF COLLAGENASE-1 AND STROMELYSIN-I METALLOPROTEASES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND METHODS OF THEIR USE

Publication Number WO/1996/040204
Publication Date 19.12.1996
International Application No. PCT/US1996/009877
International Filing Date 06.06.1996
Chapter 2 Demand Filed 07.01.1997
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07C 323/60 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50containing thio groups and carboxyl groups bound to the same carbon skeleton
51having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
60with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
C07D 209/48 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
44Iso-indoles; Hydrogenated iso-indoles
48with oxygen atoms in positions 1 and 3, e.g. phthalimide
C07K 5/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07C 323/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50containing thio groups and carboxyl groups bound to the same carbon skeleton
51having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
60with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
C07D 209/48
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
44Iso-indoles; Hydrogenated iso-indoles
48with oxygen atoms in positions 1 and 3, e.g. phthalimide
C07K 5/06043
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06008with the first amino acid being neutral
06017and aliphatic
06034the side chain containing 2 to 4 carbon atoms
06043Leu-amino acid
Applicants
  • AFFYMAX TECHNOLOGIES, N.V. [NL]/[NL] (AllExceptUS)
  • CAMPBELL, David, A. [US]/[US] (UsOnly)
  • PATEL, Dinesh, V. [US]/[US] (UsOnly)
  • XIAO, Xiao, Y. [US]/[US] (UsOnly)
Inventors
  • CAMPBELL, David, A.
  • PATEL, Dinesh, V.
  • XIAO, Xiao, Y.
Agents
  • GARRETT-WACKOWSKI, Eugenia
Priority Data
08/482,21107.06.1995US
08/549,34627.10.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL INHIBITORS OF COLLAGENASE-1 AND STROMELYSIN-I METALLOPROTEASES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND METHODS OF THEIR USE
(FR) NOUVEAUX INHIBITEURS DES METALLOPROTEASES DE COLLAGENASE-1 ET DE STROMELYSINE-I, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET LEURS PROCEDES D'UTILISATION
Abstract
(EN)
Disclosed are novel inhibitors of collagenase-1 and stromelysin-I metalloproteases. The disclosed inhibitors are mercaptoketone and mercaptoalcohol compounds which are useful in pharmaceutical compositions and methods for treating or controlling disease states or conditions which involve tissue breakdown, for example, arthropathy, dermatological conditions, bone resorption, inflammatory diseases, and tumor invasion and in the promotion of wound healing.
(FR)
L'invention concerne de nouveaux inhibiteurs des métalloprotéases de collagénase-1 et de stromélysine-I. Ces inhibiteurs sont des composés de mercaptocétone et de mercapto-alcool utiles dans des compositions pharmaceutiques et dans des procédés pour traiter ou enrayer des états pathologiques qui impliquent la dégradation des tissus, par exemple l'arthropathie, les troubles dermatologiques, la résorption osseuse, les maladies inflammatoires et l'invasion par des tumeurs, ainsi que pour promouvoir la cicatrisation.
Also published as
Latest bibliographic data on file with the International Bureau