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1. WO1996040189 - PEPTIDES AND COMPOUNDS THAT BIND TO A RECEPTOR

Publication Number WO/1996/040189
Publication Date 19.12.1996
International Application No. PCT/US1996/008998
International Filing Date 05.06.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 7/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
02Linear peptides containing at least one abnormal peptide link
C07K 14/52 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/52
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
C07K 7/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
02Linear peptides containing at least one abnormal peptide link
C12Q 1/6811
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6811Selection methods for production or design of target specific oligonucleotides or binding molecules
Applicants
  • GLAXO GROUP LIMITED [GB]/[GB] (AllExceptUS)
  • DOWER, William, J. [US]/[US] (UsOnly)
  • BARRETT, Ronald, W. [US]/[US] (UsOnly)
  • CWIRLA, Steven, E. [US]/[US] (UsOnly)
  • DUFFIN, David, J. [US]/[US] (UsOnly)
  • GATES, Christian, M. [US]/[US] (UsOnly)
  • JOHNSON, Sherril, S. [US]/[US] (UsOnly)
  • MATTHEAKIS, Larry, C. [US]/[US] (UsOnly)
  • SCHATZ, Peter, J. [US]/[US] (UsOnly)
  • WAGSTROM, Christopher, R. [US]/[US] (UsOnly)
  • WRIGHTON, Nicholas, C. [GB]/[US] (UsOnly)
Inventors
  • DOWER, William, J.
  • BARRETT, Ronald, W.
  • CWIRLA, Steven, E.
  • DUFFIN, David, J.
  • GATES, Christian, M.
  • JOHNSON, Sherril, S.
  • MATTHEAKIS, Larry, C.
  • SCHATZ, Peter, J.
  • WAGSTROM, Christopher, R.
  • WRIGHTON, Nicholas, C.
Agents
  • FITTS, Renee, A.
Priority Data
08/472,37107.06.1995US
08/473,60407.06.1995US
08/476,16807.06.1995US
08/478,12807.06.1995US
08/484,09007.06.1995US
08/485,30107.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PEPTIDES AND COMPOUNDS THAT BIND TO A RECEPTOR
(FR) PEPTIDES ET COMPOSES SE FIXANT A UN RECEPTEUR
Abstract
(EN)
Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
(FR)
La présente invention se rapporte à des peptides et à des mimétiques peptidiques qui se fixent et activent le récepteur de la thrombopoïétine. De tels peptides et mimétiques peptidiques servent dans des procédés pour le traitement de troubles hématologiques et en particulier, à la thrombocytopénie résultant de la chimiothérapie, de la radiothérapie ou des transfusions de moelle épinière, ainsi que dans des procédés diagnostiques employant des peptides et mimétiques peptidiques marqués.
Also published as
Latest bibliographic data on file with the International Bureau