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1. WO1996040122 - USE OF BENZIMIDAZOLES FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF LEUKEMIA

Publication Number WO/1996/040122
Publication Date 19.12.1996
International Application No. PCT/US1996/007445
International Filing Date 22.05.1996
Chapter 2 Demand Filed 23.12.1996
IPC
A61K 31/4184 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
4184condensed with carbocyclic rings, e.g. benzimidazoles
A61K 31/427 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
427not condensed and containing further heterocyclic rings
CPC
A61K 31/4184
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41641,3-Diazoles
4184condensed with carbocyclic rings, e.g. benzimidazoles
A61K 31/427
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
425Thiazoles
427not condensed and containing further heterocyclic rings
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
Y02A 50/30
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50in human health protection
30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applicants
  • THE PROCTER & GAMBLE COMPANY [US]/[US]
Inventors
  • CAMDEN, James, Berger
Agents
  • REED, T., David
Priority Data
08/473,81707.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF BENZIMIDAZOLES FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF LEUKEMIA
(FR) UTILISATION DE BENZIMIDAZOLES DANS LA FABRICATION D'UN MEDICAMENT DESTINE AU TRAITEMENT DE LA LEUCEMIE
Abstract
(EN)
A pharmaceutical composition for the treatment of leukemia in mammals is disclosed. The particular fungicide used is a benzimidazole derivative of formula (I), wherein X is hydrogen, halogen, alkyl of less than 7 carbon atoms or alkoxy of less than 7 carbon atoms; n is a positive integer of less than 4; Y is hydrogen, chlorine, nitro, methyl or ethyl; and R is hydrogen or an alkyl group having from 1 to 8 carbon atoms, and R2 is 4-thiazolyl or NHCOOR1 wherein R1 is aliphatic hydrocarbon of less than 7 carbon atoms or the pharmaceutically acceptable inorganic or acid addition salts thereof.
(FR)
On décrit une composition pharmaceutique destinée au traitement de la leucémie chez les mammifères. Le fongicide utilisé en particulier est un dérivé benzimidazole de la formule (I), ou des sels inorganiques ou d'addition d'acide de celui-ci, acceptables sur le plan pharmacologique. Dans cette formule, X représente hydrogène, halogène, alkyle possédant moins de 7 atomes de carbone, ou alcoxy possédant moins de 7 atomes de carbone; n est un nombre positif entier inférieur à 4; Y représente hydrogène, chlore, nitro, méthyle ou éthyle; R représente hydrogène ou un groupe alkyle possédant 1 à 8 atomes de carbone, et R2 représente 4-thiazolyle ou NHCOOR1 dans lequel R1 représente un hydrocarbure aliphatique possédant moins de 7 atomes de carbone.
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