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1. WO1996040049 - PEPTIDE/PROTEIN SUSPENDED FORMULATIONS

Publication Number WO/1996/040049
Publication Date 19.12.1996
International Application No. PCT/US1996/007377
International Filing Date 22.05.1996
Chapter 2 Demand Filed 27.12.1996
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 47/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols ; Poloxamers; PEG/POE alkyl ethers
A61K 47/32 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61K 47/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
38Cellulose; Derivatives thereof
CPC
A61K 47/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
A61K 47/32
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers ; , poly(meth)acrylates, or polyvinyl pyrrolidone
A61K 47/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
38Cellulose; Derivatives thereof
A61K 9/0004
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
Applicants
  • ALZA CORPORATION [US]/[US] (AllExceptUS)
  • ECKENHOFF, Bonnie, J. [US]/[US] (UsOnly)
  • HOLLADAY, Leslie, A. [US]/[US] (UsOnly)
  • LEONARD, John, Joseph, Jr. [US]/[US] (UsOnly)
  • LEUNG, Iris, K., M. [GB]/[US] (UsOnly)
  • TAO, Sally, A. [US]/[US] (UsOnly)
  • MAGRUDER, Judy, A. [US]/[US] (UsOnly)
  • CARR, John, P. [US]/[US] (UsOnly)
  • WRIGHT, Jeremy [US]/[US] (UsOnly)
Inventors
  • HOLLADAY, Leslie, A.
  • LEONARD, John, Joseph, Jr.
  • LEUNG, Iris, K., M.
  • TAO, Sally, A.
  • MAGRUDER, Judy, A.
  • CARR, John, P.
  • WRIGHT, Jeremy
  • ECKENHOFF, James, B.
Agents
  • DILLAHUNTY, Mary, Ann
Priority Data
08/475,23807.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PEPTIDE/PROTEIN SUSPENDED FORMULATIONS
(FR) PREPARATIONS DE SUSPENSION DES PEPTIDES OU DES PROTEINES
Abstract
(EN)
The present invention provides improved compositions for improving the chemical and physical stability of peptides and proteins. The invention provides a liquid beneficial agent formulation containing a liquid suspension comprising at least 5 % by weight beneficial agent and having a viscosity and beneficial agent size which minimizes setting of the agent in suspension over the extended delivery period.
(FR)
La présente invention concerne des compositions améliorées, destinées à renforcer la stabilité chimique et physique des peptides et des protéines. Elle se rapporte à une formulation d'agent liquide bénéfique qui contient une suspension liquide comportant au moins 5 % en poids d'agent bénéfique, et dont la viscosité et la taille réduisent au minimum la sédimentation de l'agent en suspension durant la période de libération prolongée.
Latest bibliographic data on file with the International Bureau