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1. WO1996039829 - NEW CRYPTOPHYCINS

Publication Number WO/1996/039829
Publication Date 19.12.1996
International Application No. PCT/US1996/009666
International Filing Date 07.06.1996
Chapter 2 Demand Filed 07.01.1997
IPC
A61K 31/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
C07D 273/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
273Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/-C07D271/183
CPC
A61K 31/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
C07D 273/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
273Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
C07D 307/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02not condensed with other rings
04having no double bonds between ring members or between ring members and non-ring members
18with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20Oxygen atoms
C07D 413/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
Y10S 930/27
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
930Peptide or protein sequence
01Peptide or protein sequence
27Cyclic peptide or cyclic protein
Applicants
  • UNIVERSITY OF HAWAII [US]/[US] (AllExceptUS)
  • WAYNE STATE UNIVERSITY [US]/[US] (AllExceptUS)
  • MOORE, Richard, E. [US]/[US] (UsOnly)
  • SMITH, Charles, D. [US]/[US] (UsOnly)
  • PATTERSON, Gregory, M., L. [US]/[US] (UsOnly)
  • MOOBERRY, Susan, L. [US]/[US] (UsOnly)
  • CORBETT, Thomas, H. [US]/[US] (UsOnly)
  • VALERIOTE, Frederick, A. [CA]/[US] (UsOnly)
  • GOLAKOTI, Trimurtulu [IN]/[US] (UsOnly)
Inventors
  • MOORE, Richard, E.
  • SMITH, Charles, D.
  • PATTERSON, Gregory, M., L.
  • MOOBERRY, Susan, L.
  • CORBETT, Thomas, H.
  • VALERIOTE, Frederick, A.
  • GOLAKOTI, Trimurtulu
Agents
  • YOUNG, Barry, N.
Priority Data
08/482,14107.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NEW CRYPTOPHYCINS
(FR) NOUVELLES CRYPTOPHYCINES
Abstract
(EN)
The present invention provides novel cryptophycin compounds having structure (I). The present invention also provides methods for producing novel cryptophycins from the $i(Nostoc) sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided by the present invention, as are methods for using novel cryptophycins to inhibit the proliferation of hyperproliferative cells. The present invention further provides methods for using novel cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.
(FR)
L'invention concerne de nouveaux composés de cryptophycine ayant la formule (I), des procédés pour produire ces nouvelles cryptophycines à partir d'algues bleu-vert (cyanobactéries) du genre $i(Nostoc) sp., des compositions pharmaceutiques contenant les nouvelles cryptophycines, et des procédés d'utilisation des nouvelles cryptophycines pour inhiber la prolifération de cellules hyperprolifératives, en particulier de cellules hyperprolifératives présentant des phénotypes ayant développé une résistance aux médicaments, et pour traiter des pathologies telles que les néoplasies.
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