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1. WO1996039523 - BACTERIAL PRODUCTION OF HYDROPHOBIC POLYPEPTIDES

Publication Number WO/1996/039523
Publication Date 12.12.1996
International Application No. PCT/US1996/009155
International Filing Date 05.06.1996
IPC
C07K 14/565 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
555Interferons (IFN)
565IFN-beta
C12P 21/02 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
02having a known sequence of two or more amino acids, e.g. glutathione
CPC
C07K 14/565
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
555Interferons [IFN]
565IFN-beta
C12P 21/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
02having a known sequence of two or more amino acids, e.g. glutathione
Applicants
  • CHIRON CORPORATION [US]/[US]
Inventors
  • DORIN, Glenn
  • McALARY, Patrick, J.
  • WONG, Kathleen, M.
Agents
  • CHUNG, Ling-Fong
Priority Data
08/477,31006.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BACTERIAL PRODUCTION OF HYDROPHOBIC POLYPEPTIDES
(FR) PRODUCTION BACTERIENNE DE POLYPEPTIDES HYDROPHOBES
Abstract
(EN)
Methods for the production of interferon-$g(b) polypeptides by bacterial cells, by culturing cells capable of producing IFN-$g(b) polypeptide under conditions that induce increased production of IFN-$g(b) polypeptide. Such conditions include, for example, low potassium cation concentration and/or very low sodium cation concentration and/or specific pH ranges.
(FR)
L'invention concerne des procédés de production de polypeptides d'interféron-$g(b) à l'aide de cellules bactériennes, en cultivant des cellules capables de produire un polypeptide IFN-$g(b) dans des conditions qui induisent une production accrue du polypeptide IFN-$g(b). De telles conditions comprennent, par exemple, une faible concentration de cations de potassium et/ou une très faible concentration de cations de sodium et/ou des plages spécifiques de pH.
Also published as
FI970445
NO19970514
NZ310710
Latest bibliographic data on file with the International Bureau