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1. WO1996039434 - HUMAN G-PROTEIN RECEPTOR HGBER32

Publication Number WO/1996/039434
Publication Date 12.12.1996
International Application No. PCT/US1995/007086
International Filing Date 05.06.1995
Chapter 2 Demand Filed 20.12.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 14/715 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
715for cytokines; for lymphokines; for interferons
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
08Vasodilators for multiple indications
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 9/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
12Antihypertensives
Applicants
  • HUMAN GENOME SCIENCES, INC. [US]/[US] (AllExceptUS)
  • SOPPET, Daniel, R. [US]/[US] (UsOnly)
  • LI, Yi [CN]/[US] (UsOnly)
  • ROSEN, Craig, A. [US]/[US] (UsOnly)
  • RUBEN, Steven, M. [US]/[US] (UsOnly)
Inventors
  • SOPPET, Daniel, R.
  • LI, Yi
  • ROSEN, Craig, A.
  • RUBEN, Steven, M.
Agents
  • BENSON, Robert, H.
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HUMAN G-PROTEIN RECEPTOR HGBER32
(FR) RECEPTEUR HGBER32 DE PROTEINE G HUMAINE
Abstract
(EN)
Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
(FR)
L'invention concerne des récepteurs polypeptidiques couplés par la protéine G humaine, ainsi qu'un ADN (ARN) codant pour ces polypeptides et un procédé pour produire de tels polypeptides par des techniques de recombinaison. L'invention porte également sur des méthodes d'utilisation de ces polypeptides pour identifier des antagonistes et des agonistes de tels polypeptides et des méthodes d'utilisation de ces agonistes et antagonistes pour le traitement d'états liés à une expression excessive ou insuffisante des récepteurs polypeptidiques couplés par la protéine G. L'invention porte également sur des méthodes diagnostiques permettant de détecter des mutations dans les séquences d'acide nucléique codant pour les récepteurs de la protéine G et pour détecter des modifications dans les niveaux de la forme soluble des récepteurs.
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