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1. WO1996039426 - HYPOXIA INDUCIBLE FACTOR-1 AND METHOD OF USE

Publication Number WO/1996/039426
Publication Date 12.12.1996
International Application No. PCT/US1996/010251
International Filing Date 06.06.1996
Chapter 2 Demand Filed 27.12.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 7/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
C07K 14/4702
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4702Regulators; Modulating activity
Applicants
  • THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE [US]/[US]
Inventors
  • SEMENZA, Gregg, L.
Agents
  • HAILE, Lisa, A.
Priority Data
08/480,47306.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HYPOXIA INDUCIBLE FACTOR-1 AND METHOD OF USE
(FR) FACTEUR 1 POUVANT ETRE INDUIT PAR L'HYPOXIE ET SON PROCEDE D'UTILISATION
Abstract
(EN)
The purified and characterization of hypoxia-inducible factor 1 (HIF-1) is described. HIF-1 is composed of subunits HIF-1$g(a) and HIF-1$g(b). Purified HIF-1$g(a) polypeptide, its amino acid sequence and polynucleotide sequence are provided. A HIF-1$g(a) variant that dimerizes to HIF-1$g(b) producing a nonfunctional HIF-1 complex is described. Methods for the prevention and treatment of hypoxia-related disorders are provided.
(FR)
Facteur 1 pouvant être induit par l'hypoxie (HIF-1), qui est composé de sous-unités HIF-1$g(a) et HIF-1$g(b). La présente invention concerne le polypeptide HIF-1$g(a) purifié, sa séquence d'acides aminés et sa séquence polynucléotidique, un variant HIF-1$g(a) qui dimérise avec HIF-1$g(b), produisant un complexe HIF-1 non fonctionnel, ainsi que des procédés de prévention et de traitement de troubles liés à l'hypoxie.
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