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1. WO1996039419 - COLON SPECIFIC GENES AND PROTEINS

Publication Number WO/1996/039419
Publication Date 12.12.1996
International Application No. PCT/US1995/007289
International Filing Date 06.06.1995
Chapter 2 Demand Filed 20.12.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
Applicants
  • HUMAN GENOME SCIENCES, INC. [US]/[US] (AllExceptUS)
  • YU, Guo-Liang [CN]/[US] (UsOnly)
  • ROSEN, Craig, A. [US]/[US] (UsOnly)
Inventors
  • YU, Guo-Liang
  • ROSEN, Craig, A.
Agents
  • OLSTEIN, Elliot, M.
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COLON SPECIFIC GENES AND PROTEINS
(FR) GENES ET PROTEINES SPECIFIQUES DU COLON
Abstract
(EN)
Human colon specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for colon cancer and as an agent to determine if colon cancer has metastasized. Also disclosed are antibodies specific to the colon specific gene polypeptides which may be used to target cancer cells and be used as part of a colon cancer vaccine. Methods of screening for agonists and antagonists for the polypeptides and therapeutic uses of the antagonists are disclosed.
(FR)
L'invention concerne des polypeptides de gènes spécifiques du colon humain, l'ADN (ARN) codant ces polypeptides ainsi qu'une procédure de production desdits polypeptides par des techniques de recombinaison. L'invention concerne également des procédés d'utilisation de tels polynucléotides ou polypeptides en tant que marqueurs de diagnostic dans le cas du cancer du colon et en tant qu'agent permettant de déterminer si le cancer du colon est métastasé. L'invention concerne également des anticorps spécifiques des polypeptides des gènes spécifiques du colon qui peuvent être uilisés pour cibler des cellules cancéreuses, ou comme composants d'un vaccin contre le cancer du colon. L'invention concerne en outre des procédés de criblage d'agonistes et d'antagonistes aux polypeptides ainsi que des utilisations thérapeutiques de ces antagonistes.
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