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1. WO1996039418 - HUMAN CYSTATIN E

Publication Number WO/1996/039418
Publication Date 12.12.1996
International Application No. PCT/US1995/007135
International Filing Date 05.06.1995
Chapter 2 Demand Filed 20.12.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/81 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
81Protease inhibitors
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/8139
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
81Protease inhibitors
8107Endopeptidase (E.C. 3.4.21-99) inhibitors
8139Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
C12N 2799/026
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2799Uses of viruses
02as vector
021for the expression of a heterologous nucleic acid
026where the vector is derived from a baculovirus
Applicants
  • HUMAN GENOME SCIENCES, INC. [US]/[US] (AllExceptUS)
  • NI, Jian [CN]/[US] (UsOnly)
  • YU, Guo-Liang [CN]/[US] (UsOnly)
  • GENTZ, Reiner [DE]/[US] (UsOnly)
  • ROSEN, Craig, A. [US]/[US] (UsOnly)
Inventors
  • NI, Jian
  • YU, Guo-Liang
  • GENTZ, Reiner
  • ROSEN, Craig, A.
Agents
  • SQUIRE, William
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HUMAN CYSTATIN E
(FR) CYSTATINE E HUMAINE
Abstract
(EN)
Disclosed is a human CysE polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for treating osteoporosis, tumor metastases, microbial infections, viral infection, septic shock, inflammation, retinal irritation, caries, cachicia and muscle wasting. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
(FR)
La présente invention concerne un polypeptide de CysE humaine et l'ADN (RNA) codant ce polypeptide, ainsi qu'une procédure de production dudit polypeptide par techniques de recombinaison. Elle concerne également des procédés d'utilisation dudit polypeptide dans le traitement de l'ostéoporose, de métastases tumorales, d'infections microbiennes, d'infections virales, de chocs septiques, d'inflammations, d'irritations de la rétine, de caries, de cachexie et d'atrophie musculaire. L'invention concerne également des méthodes de diagnostic permettant de détecter des mutations dans la séquence de codage et des modifications de la concentration des polypeptides dans un échantillon tiré d'un hôte.
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