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1. WO1996039409 - NITROSYLATED AND NITRATED SUPEROXIDE OXIDANTS AND REDUCTANTS

Publication Number WO/1996/039409
Publication Date 12.12.1996
International Application No. PCT/US1996/008406
International Filing Date 03.06.1996
Chapter 2 Demand Filed 13.12.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07D 211/94 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
92with a hetero atom directly attached to the ring nitrogen atom
94Oxygen atom, e.g. piperidine N-oxide
C07D 259/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
259Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
C07D 263/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02not condensed with other rings
04having no double bonds between ring members or between ring members and non-ring members
C07D 487/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
22in which the condensed system contains four or more hetero rings
C07K 5/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07D 211/94
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
92with a hetero atom directly attached to the ring nitrogen atom
94Oxygen atom, e.g. piperidine N-oxide
C07D 259/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
259Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
C07D 263/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02not condensed with other rings
04having no double bonds between ring members or between ring members and non-ring members
C07K 5/022
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
022containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
C07K 5/06026
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06008with the first amino acid being neutral
06017and aliphatic
06026the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
Applicants
  • NITROMED, INC. [US]/[US]
  • DUKE UNIVERSITY [US]/[US]
Inventors
  • STAMLER, Jonathan, S.
  • CRAPO, James, D.
  • FRIDOVICH, Irwin
  • DAY, Brian, J.
  • GARVEY, David, S.
Agents
  • HERRON, Charles, J.
Priority Data
08/463,97405.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NITROSYLATED AND NITRATED SUPEROXIDE OXIDANTS AND REDUCTANTS
(FR) OXYDANTS ET REDUCTEURS NITROSYLES ET NITRES DE SUPEROXYDES
Abstract
(EN)
A compound comprising a superoxide oxidant or reductant to which is directly or indirectly linked an NO or NO2 group. More particularly, compounds having the formula: D-X-R, wherein R is a moiety that oxidizes and/or reduces superoxide to oxygen and/or hydrogen peroxide under physiological conditions; X is S, N, O or C; and D is NO or NO2. R can be a functionality containing an unpaired electron, a cation such as a physiologically acceptable metal ion, hydrogen or a protective group or R can be a complex of a transition metal and a macrocyclic ligand that dismutes superoxide under physiological conditions. These compounds can be used alone or in combination or concurrently with other therapeutic agents, particularly nitric oxide adducts. Further, the invention provides that the superoxide oxidants or reductants which have not been linked to an NO or NO2 group can be administered in combination or concurrently with nitric oxide or nitric oxide adducts. They are useful for preventing superoxide cell damage and for treating inflammatory disorders in mammals, particularly humans.
(FR)
Composé constitué d'un oxydant ou d'un réducteur de superoxyde auquel est directement ou indirectement lié un groupe NO ou NO2. L'invention concerne en particulier les composés de formule D-X-R, dans lesquels R est une fraction oxydant et/ou réduisant le superoxyde en oxygène et/ou en peroxyde d'hydrogène dans les conditions physiologiques; X est S, N, O ou C et D est NO ou NO2. R peut être une fonctionnalité comprenant un électron non apparié, un cation tel qu'un ion métal physiologiquement tolérable, hydrogène ou un groupe protecteur, ou R peut être un complexe d'un métal de transition et d'un ligand macrocyclique opérant une dismutation du superoxyde dans les conditions physiologiques. Ces composés peuvent être utilisés seuls ou en association ou concurremment avec d'autres agents thérapeutiques, en particulier les composés d'addition d'oxyde nitrique. De plus, selon l'invention, les oxydants ou réducteurs de superoxydes n'ayant pas de liaison à un groupe NO ou NO2 peuvent être administrés en association ou concurremment avec de l'oxyde nitrique ou des composés d'addition d'oxyde nitrique. Ces composés sont utiles à la prévention des dommages aux cellules par les superoxydes et au traitement des troubles inflammatoires chez les mammifères, en particulier chez l'homme.
Also published as
Latest bibliographic data on file with the International Bureau