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1. WO1996039202 - BIOCOMPATIBLE HYDROXYAPATITE FORMULATIONS AND USES THEREFOR

Publication Number WO/1996/039202
Publication Date 12.12.1996
International Application No. PCT/US1996/008652
International Filing Date 03.06.1996
Chapter 2 Demand Filed 06.01.1997
IPC
A61F 2/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61L 24/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
02containing inorganic materials
A61L 27/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
02Inorganic materials
12Phosphorus-containing materials, e.g. apatite
A61L 27/32 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
28Materials for coating prostheses
30Inorganic materials
32Phosphorus-containing materials, e.g. apatite
CPC
A61F 2310/00293
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2310Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
00005The prosthesis being constructed from a particular material
00179Ceramics or ceramic-like structures
00293containing a phosphorus-containing compound, e.g. apatite
A61F 2310/00796
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2310Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
00389The prosthesis being coated or covered with a particular material
00592Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
00796Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
A61L 24/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
02containing inorganic materials
A61L 27/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
02Inorganic materials
12Phosphorus-containing materials, e.g. apatite
A61L 27/32
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
28Materials for coating prostheses
30Inorganic materials
32Phosphorus-containing materials, e.g. apatite
A61L 27/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
50Materials characterised by their function or physical properties ; , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
54Biologically active materials, e.g. therapeutic substances
Applicants
  • OSTEOGENICS INC. [US]/[US]
Inventors
  • CONSTANTINO, Peter, D.
  • FRIEDMAN, Craig, D.
  • SEN, Arup
Agents
  • JOHNSON, Jay, B.
  • TATE, Rodger, L.
Priority Data
08/468,08406.06.1995US
08/469,90906.06.1995US
08/471,21606.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BIOCOMPATIBLE HYDROXYAPATITE FORMULATIONS AND USES THEREFOR
(FR) PREPARATIONS BIOCOMPATIBLES D'HYDROXYAPATITE ET LEURS UTILISATIONS
Abstract
(EN)
A biocompatible hydroxyapatite formulation is provided. The formulation is precipitated from a mixture of a liquid phase, a bioactive or biocompatible additive which may be any of a number of bioreactive or other substances, and a base combination of calcium phosphate salts. The liquid phase and the additive may be combined to produce an augmented liquid phase, which is then mixed with the base salt combination. The additive is chosen to achieve a desired effect during administration of the formulation to a plant or animal. The additive is released into the surrounding physiological milieu and the hydroxyapatite component is resorbed.
(FR)
L'invention porte sur une préparation biocompatible d'hydroxyapatite obtenue par précipitation d'un mélange d'une phase liquide, d'un additif biocompatible ou bioactif, qui peut être choisi parmi différents bioréacteurs ou d'autres substances, et une combinaison basique de sels phosphocalciques. La phase liquide et l'additif peuvent être combinés pour produire une phase liquide plus importante qui est ensuite mélangée avec la combinaison de sels basiques. L'additif est choisi pour permettre d'obtenir l'effet désiré lors de l'administration de la préparation à un végétal ou à un animal. L'additif est libéré dans le milieu physiologique environnant et l'hydroxyapatite est résorbée.
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