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1. WO1996039158 - PINEAL GLAND SPECIFIC GENE-1

Publication Number WO/1996/039158
Publication Date 12.12.1996
International Application No. PCT/US1995/007067
International Filing Date 05.06.1995
Chapter 2 Demand Filed 20.12.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/575 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 5/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5Drugs for disorders of the endocrine system
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/575
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
Applicants
  • HUMAN GENOME SCIENCES, INC. [US]/[US] (AllExceptUS)
  • HE, Wei, Wu [CN]/[US] (UsOnly)
  • ROSEN, Craig, A. [US]/[US] (UsOnly)
Inventors
  • HE, Wei, Wu
  • ROSEN, Craig, A.
Agents
  • SQUIRE, William
  • BENSON, Robert, H.
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PINEAL GLAND SPECIFIC GENE-1
(FR) GENE 1 SPECIFIQUE DE LA GLANDE PINEALE
Abstract
(EN)
Human pineal gland specific gene-1 polypeptides and DNA (RNA) encoding such polypeptides and a procedure is disclosed. Also disclosed are methods for utilizing such polypeptides for the regulation of the pituitary gland and to modulate biological rhythms. Agonists and antagonists against such polypeptides and their use as a therapeutic to control the actions of such polypeptides are also disclosed. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the polypeptides and for detecting altered levels of the polypeptide in a host.
(FR)
L'invention porte sur des polypeptides du gène 1 spécifique de la glande pinéale humaine, sur l'ADN (ARN) codant pour de tels polypeptides, ainsi que sur des procédés associés. L'invention porte en particulier sur des procédés d'utilisation de ces polypeptides pour la régulation du fonctionnement de l'hypophyse et pour la modulation de rythmes biologiques. L'invention porte également sur des agonistes et des antagonistes de ces polypeptides et sur leur utilisation thérapeutique pour moduler l'activité de ces polypeptides. On décrit également des tests diagnostiques pour détecter des mutations dans les polynucléotides codant pour les polypeptides et pour détecter des modifications du taux d'un tel polypeptide chez un hôte.
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