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1. WO1996038559 - CHEMOKINE N-TERMINAL DELETION MUTATIONS

Publication Number WO/1996/038559
Publication Date 05.12.1996
International Application No. PCT/US1996/007368
International Filing Date 22.05.1996
Chapter 2 Demand Filed 30.12.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/52 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 23/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
23Anaesthetics
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
Applicants
  • DANA FARBER CANCER INSTITUTE [US]/[US]
Inventors
  • ROLLINS, Barrett
  • ZHANG, Yujun
Agents
  • BROOK, David, E.
Priority Data
08/455,62931.05.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CHEMOKINE N-TERMINAL DELETION MUTATIONS
(FR) MUTATIONS DE DELETION DE L'EXTREMITE N DE CHEMOKINE
Abstract
(EN)
The invention relates to mutant chemokines and pharmaceutical compositions thereof, wherein the mutant inhibits the corresponding endogenous chemokine from binding or activating a responsive receptor. The claimed mutant chemokines can be administered to a patient for the treatment or prophylaxis of a chemokine-mediated disease. The invention further relates to isolated DNAs encoding the mutant chemokines, vectors and recombinant host cells containing the same.
(FR)
L'invention concerne des chémokines mutantes, ainsi que leurs compositions pharmaceutiques, où la mutation empêche la chémokine endogène correspondante de se fixer à un récepteur sensible ou d'activer ledit récepteur. Ces chémokines mutantes peuvent être administrées à un patient, dans le but de réaliser le traitement ou la prophylaxie d'une maladie provoquée par les chémokines. L'invention concerne, de plus, des ADNs isolés codants les chémokines mutantes, ainsi que des vecteurs et des cellules hôtes recombinées les contenant.
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