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1. WO1996038161 - DRUG DELIVERY ENHANCEMENT VIA MODIFIED SAPONINS

Publication Number WO/1996/038161
Publication Date 05.12.1996
International Application No. PCT/US1996/008711
International Filing Date 03.06.1996
Chapter 2 Demand Filed 02.01.1997
IPC
A61K 38/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
28Insulins
A61K 39/39 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 47/46 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
C07J 63/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
63Steroids in which the cyclopentahydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
CPC
A61K 2039/55577
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55577Saponins; Quil A; QS21; ISCOMS
A61K 31/704
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034attached to a carbocyclic compound, e.g. phloridzin
704attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
A61K 38/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
28Insulins
A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 47/46
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
A61K 9/0014
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0014Skin, i.e. galenical aspects of topical compositions
Applicants
  • AQUILA BIOPHARMACEUTICALS, INC. [US]/[US]
Inventors
  • KENSIL, Charlotte, A.
  • SOLTYSIK, Sean
  • MARCIANI, Dante, J.
  • RECCHIA, Joanne
Agents
  • BAKER, Hollie, L.
Priority Data
08/459,50202.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DRUG DELIVERY ENHANCEMENT VIA MODIFIED SAPONINS
(FR) AMELIORATION DE L'ADMINISTRATION DE MEDICAMENTS PAR SAPONINES MODIFIEES
Abstract
(EN)
Disclosed herein are modified saponins or fractions thereof obtainable by modification of a crude $i(Quillaja saponaria) extract or by modification of purified saponins obtainable from a crude $i(Quillaja saponaria) extract useful in pharmaceutical compositions for enhancing the transport of pharmacologically active substances across mucous membranes of an animal. Also disclosed are modified saponins having reduced irritability wherein the aldehyde group is reduced and the fatty acid moiety may be removed by hydrolysis. Also disclosed are pharmaceutical compositions comprising the modified saponins of the invention.
(FR)
La présente invention concerne des saponines modifiées ou des fractions de celles-ci, qu'il est possible d'obtenir par modification d'un extrait brut de $i(Quillaja saponaria) ou par modification de saponines purifiées que l'on peut obtenir à partir d'un extrait brut de $i(Quillaja saponaria), lesquelles sont utiles dans des compositions pharmaceutiques pour améliorer le transport de substances actives pharmacologiquement à travers les muqueuses d'un animal. Elle concerne également des saponines modifiées présentant une irritabilité réduite, dans lesquelles le groupe aldéhyde est réduit et la fraction d'acide gras peut être enlevée par hydrolyse. Elle concerne aussi des compositions pharmaceutiques comprenant les saponines modifiées de l'invention.
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