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1. WO1996038146 - WATER SOLUBLE CAMPTOTHECIN ANALOGS

Publication Number WO/1996/038146
Publication Date 05.12.1996
International Application No. PCT/US1996/008283
International Filing Date 30.05.1996
Chapter 2 Demand Filed 05.12.1996
IPC
C07D 491/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
22in which the condensed system contains four or more hetero rings
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 491/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
22in which the condensed system contains four or more hetero rings
Applicants
  • SMITHKLINE BEECHAM CORPORATION [US]/[US] (AllExceptUS)
  • BERGES, David, A. [US]/[US] (UsOnly)
  • TAGGART, John, J. [US]/[US] (UsOnly)
Inventors
  • BERGES, David, A.
  • TAGGART, John, J.
Agents
  • STERCHO, Yuriy, P.
Priority Data
08/454,79331.05.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) WATER SOLUBLE CAMPTOTHECIN ANALOGS
(FR) ANALOGUES DE LA CAMPTOTHECINE SOLUBLES DANS L'EAU
Abstract
(EN)
The present invention provides a water soluble camptothecin analog of Formula (I), which is particularly useful as an antineoplastic agent; pharmaceutical compositions thereof; and a method of treating cancer in an animal in need thereof, including human beings, comprising inhibition of the growth of tumor cells in said animal by administration of an effective amount of a compound of Formula (I).
(FR)
La présente invention décrit un analogue de la camptothécine soluble dans l'eau de formule (I), particulièrement utile comme agent antinéoplasique; des compositions pharmaceutiques à partir de ce dernier; et une méthode de traitement du cancer chez un animal nécessitant un tel traitement, y compris chez l'homme, consistant à inhiber la croissance de cellules tumorales chez ledit animal en lui administrant une quantité efficace d'un composé de formule (I).
Also published as
Latest bibliographic data on file with the International Bureau