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1. WO1996031620 - SCREENING METHOD FOR INHIBITORS OF FARNESYL PYROSPHOSPHATE SYNTHASE

Publication Number WO/1996/031620
Publication Date 10.10.1996
International Application No. PCT/GB1996/000694
International Filing Date 23.03.1996
Chapter 2 Demand Filed 31.07.1996
IPC
C12Q 1/48 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
48involving transferase
CPC
C12Q 1/48
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
48involving transferase
Applicants
  • ZENECA LIMITED [GB]/[GB] (AllExceptUS)
  • RIDLEY, Stuart, Martin [GB]/[GB] (UsOnly)
  • HUGHES, Joy, Lillias [GB]/[GB] (UsOnly)
Inventors
  • RIDLEY, Stuart, Martin
  • HUGHES, Joy, Lillias
Agents
  • ROBERTS, Alison, Christine
Priority Data
9507131.206.04.1995GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SCREENING METHOD FOR INHIBITORS OF FARNESYL PYROSPHOSPHATE SYNTHASE
(FR) PROCEDE DE DETERMINATION D'INHIBITEURS DE FARNESYL-PYROPHOSPHATE SYNTHASE
Abstract
(EN)
A method for determining whether a compound is an inhibitor of FPPS, the method comprising incubating the compound with IPP and GPP in the presence of FPPS and detecting the presence or absence of pyrophosphate.
(FR)
Procédé permettant de déterminer si un composé est un inhibiteur de farnésyl-pyrophophate synthase (FPPS), qui consiste à faire incuber ledit composé avec de l'isopentyl-pyrophosphate (IPP) et du géranylpyrophospate en présence de FPPS et à détecter la présence ou l'absence de pyrophosphate.
Also published as
Latest bibliographic data on file with the International Bureau