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1. WO1996031531 - FLUORESCENT PEPTIDES

Publication Number WO/1996/031531
Publication Date 10.10.1996
International Application No. PCT/CA1996/000207
International Filing Date 04.04.1996
Chapter 2 Demand Filed 02.11.1996
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
06
having 5 to 11 amino acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
14
Angiotensins; Related peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
575
Hormones
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
C07K 7/06 (2006.01)
C07K 7/14 (2006.01)
C07K 14/575 (2006.01)
G01N 33/50 (2006.01)
G01N 33/569 (2006.01)
CPC
C07K 14/575
C07K 14/57536
C07K 14/57563
C07K 7/06
C07K 7/14
G01N 33/5094
Applicants
  • ADVANCED BIOCONCEPT, INC. [CA/CA]; Suite 720 1801 McGill College Montreal, Quebec H3A 2N4, CA
Inventors
  • DESJARDINS, Clarissa; CA
  • FAURE, Marie-Pierre; CA
  • BEAUDET, Alain; CA
  • VINCENT, Jean-Pierre; FR
  • GAUDRIAULT, Georges; FR
Agents
  • ROBINSON, Christopher, J. ; Smart & Biggar Vancouver Centre, Suite 2200 650 West Georgia Street Box 11560 Vancouver, British Columbia V6B 4N8, CA
Priority Data
08/416,00704.04.1995US
08/475,75107.06.1995US
08/504,85620.07.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FLUORESCENT PEPTIDES
(FR) PEPTIDES FLUORESCENT
Abstract
(EN)
The invention provides biologically active compounds of formula (I) where R1 is a light-emitting moiety and R7 is a peptide of between 2 and 200 amino acids. X is selected from the group including =O, =S, -OH, =C=O, =NH, -H, -OR, -NR, -R, -R3R4, wherein each R, R4 and R3, independently, is H or a C1-C6 branched or unbranched, substituted or unsubstituted, alkyl. The compounds are both biologically active and optically detectable. The peptide is chemically attached to the light-emitting moiety at an amino acid position which is not involved in binding to the peptide's receptor. In this way, the peptide's affinity for its receptor is not significantly decreased, and the compound retains high biological activity and can be easily detected using standard optical means.
(FR)
L'invention concerne des composés actifs sur le plan biologique ayant la formule (I). Dans cette formule, R1 est un groupe émettant de la lumière et R7 est un peptide comprenant entre 2 et 200 acides aminés. X est choisi dans le groupe constitué par =O, =C=O, =NH, -H, -OR, -NR, -R, -R3R4, où chaque élément R, R4 et R3 est, d'une manière indépendante, H ou un alkyle en C1-C6 ramifié ou non, substitué ou non. Les composés sont en même temps actifs sur le plan biologique et détectables par des moyens optiques. Le peptide est fixé chimiquement au groupe émettant de la lumière par un acide aminé dans une position qui n'est pas impliquée dans la fixation au récepteur du peptide. De cette manière, l'affinité du peptide pour son récepteur n'est pas diminuée d'une manière significative et le composé conserve une activité biologique élevée et peut facilement être détecté en utilisant des moyens optiques connus.
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