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1. WO1996030396 - $g(b)-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS

Publication Number WO/1996/030396
Publication Date 03.10.1996
International Application No. PCT/US1996/004115
International Filing Date 25.03.1996
Chapter 2 Demand Filed 23.10.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
CPC
A61K 38/005
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
005Enzyme inhibitors
C07K 5/0202
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
0202containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
Applicants
  • MOLECUMETICS LTD. [US]/[US] (AllExceptUS)
  • KAHN, Michael [US]/[US] (UsOnly)
Inventors
  • KAHN, Michael
Agents
  • HERMANNS, Karl, R.
  • GOWSHALL, Jon, V.
Priority Data
08/410,51824.03.1995US
08/549,00627.10.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) $g(b)-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS
(FR) IMITATEURS DE FEUILLETS $g(b) ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE PROTEASE
Abstract
(EN)
There are disclosed $g(b)-sheet mimetics and methods relating to the same for imparting or stabilizing the $g(b)-sheet structure of a peptide, protein or molecule. In one aspect, the $g(b)-sheet mimetics are covalently attached at the end or within the length of the peptide or protein. The $g(b)-sheet mimetics have utility as protease inhibitors generally, including activity as serine protease inhibitors such as thrombin, elastase and Factor X.
(FR)
L'invention concerne des imitateurs de feuillets $g(b) et des procédés afférents destinés à conférer ou à stabiliser la structure de feuillets $g(b) d'un peptide, d'une protéine ou d'une molécule. Dans un aspect, les imitateurs de feuillets $g(b) sont fixés de manière covalente à l'extrémité ou dans la longueur du peptide ou de la protéine. Les imitateurs de feuillets $g(b) présentent une utilité, d'une manière générale, en tant qu'inhibiteurs de protéase, y compris une activité d'inhibiteurs de sérine protéase telle que la thrombine, l'élastase et le facteur X.
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