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1. WO1996029863 - LONG TERM STORAGE OF RED CELLS IN UNFROZEN SOLUTION

Publication Number WO/1996/029863
Publication Date 03.10.1996
International Application No. PCT/US1996/003994
International Filing Date 22.03.1996
Chapter 2 Demand Filed 17.10.1996
IPC
A01N 1/02 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
A61K 35/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
18Erythrocytes
CPC
A01N 1/02
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
A01N 1/0221
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
0205Chemical aspects
021Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
0221Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
A61K 35/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
18Erythrocytes
Applicants
  • ORGAN, INC. [US]/[US]
Inventors
  • MERYMAN, Harold, T.
Agents
  • OLIFF, James, A.
Priority Data
08/409,59924.03.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LONG TERM STORAGE OF RED CELLS IN UNFROZEN SOLUTION
(FR) STOCKAGE DE LONGUE DUREE DE GLOBULES ROUGES EN SOLUTION NON CONGELEE
Abstract
(EN)
A method for prolonging storage shelf-life of red blood cells under refrigerated conditions includes separating plasma from the red blood cells while retaining residual plasma and adding a biologically compatible solution having an effective osmolality of less than 70 mOsm to the red blood cells. The biologically compatible solution preferably includes at least one penetrating solute that penetrates red cells more slowly than water and substantially no non-penetrating anions and non-penetrating non-electrolytes.
(FR)
L'invention porte sur un procédé permettant de prolonger la durée de stockage de globules rouges réfrigérés consistant à séparer le plasma d'avec les globules rouges, à conserver le plasma résiduel, à ajouter aux globules rouges une solution à compatibilité biologique présentant une osmolalité efficace de moins de 70 mOsm vis à vis des globules rouges et comprenant au moins un soluté pénétrant les globules rouges plus lentement que l'eau, et sensiblement exempt d'anions non pénétrants et de non électrolytes non pénétrants.
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