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1. WO1996027019 - TRANSGENIC ANIMALS AS MODEL OF PSORIASIS

Publication Number WO/1996/027019
Publication Date 06.09.1996
International Application No. PCT/GB1996/000431
International Filing Date 26.02.1996
Chapter 2 Demand Filed 12.08.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C12N 15/85 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
CPC
A01K 2207/15
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2207Modified animals
15Humanized animals
A01K 2217/00
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
A01K 2217/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
A01K 2227/105
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
105Murine
A01K 2267/0325
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
03Animal model, e.g. for test or diseases
0306Animal model for genetic diseases
0325Animal model for autoimmune diseases
A01K 67/0278
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
0275Genetically modified vertebrates, e.g. transgenic
0278Humanized animals, e.g. knockin
Applicants
  • IMPERIAL CANCER RESEARCH TECHNOLOGY LIMITED [GB]/[GB] (AllExceptUS)
  • WATT, Fiona, Mary [GB]/[GB] (UsOnly)
  • CARROLL, Joseph, Michael [US]/[GB] (UsOnly)
Inventors
  • WATT, Fiona, Mary
  • CARROLL, Joseph, Michael
Agents
  • BASSETT, Richard
Priority Data
9503868.325.02.1995GB
9514535.515.07.1995GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRANSGENIC ANIMALS AS MODEL OF PSORIASIS
(FR) ANIMAUX TRANSGENIQUES UTILISES COMME MODELE DU PSORIASIS
Abstract
(EN)
A nucleic acid construct comprising a promoter capable of directing expression in the suprabasal cells of the epidermis and means to cause expression of an integrin subunit in the suprabasal cells. Preferably the means to cause expression of an integrin subunit is an integrin subunit coding sequence. A transgenic animal which expresses an $g(a) subunit and a $g(b) subunit of integring in the suprabasal cells of the epidermis and methods for making the transgenic animals. A least some of the transgenic animals are useful models of human disease, especially psoriasis. A method of treating psoriasis comprising administering to the patient a compound which modulates integrin function.
(FR)
La présente invention concerne une construction d'acides nucléiques comportant un promoteur capable de diriger une expression dans les cellules suprabasales de l'épiderme ainsi qu'un élément permettant de provoquer l'expression d'une sous-unité d'intégrine dans ces cellules suprabasales. De préférence, cet élément permettant de provoquer l'expression d'une sous-unité d'intégrine est une séquence codante d'une sous-unité d'intégrine. Cette invention concerne également un animal transgénique qui exprime une sous-unité $g(a) et une sous-unité $g(b) d'intégrine dans les cellules suprabasales de l'épiderme ainsi que des procédés de préparation de ces animaux transgéniques. Certains, au moins, de ces animaux transgéniques s'avèrent utiles comme modèles de troubles humains, et en particulier du psoriasis. Cette invention se rapporte aussi à un procédé de traitement du psoriasis consistant à administrer à un patient un composé qui permet de moduler la fonction d'intégrine.
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