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1. WO1996027009 - HUMAN AMINE TRANSPORTER

Publication Number WO/1996/027009
Publication Date 06.09.1996
International Application No. PCT/US1995/002645
International Filing Date 01.03.1995
Chapter 2 Demand Filed 01.10.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
20Hypnotics; Sedatives
A61P 25/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
A61P 25/26
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
26Psychostimulants, e.g. nicotine, cocaine
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applicants
  • HUMAN GENOME SCIENCES, INC. [US]/[US] (AllExceptUS)
  • LI, Yi [CN]/[US] (UsOnly)
  • CAO, Liang [CN]/[GB] (UsOnly)
  • ROSEN, Craig, A. [US]/[US] (UsOnly)
Inventors
  • LI, Yi
  • CAO, Liang
  • ROSEN, Craig, A.
Agents
  • STERNE, Robert, Greene
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HUMAN AMINE TRANSPORTER
(FR) TRANSPORTEUR D'AMINE HUMAINE
Abstract
(EN)
A Human amine transporter polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting agonists and antagonists to such polypeptide and the use of agonists and antagonists for treating diseases related to the under-expression and over-expression of the Human amine transporter of the present invention. Also disclosed are methods for detecting mutations in the nucleic acid sequence encoding the polypeptide and for detecting altered levels of the soluble form of the polypeptide.
(FR)
L'invention, qui traite d'un polypeptide transporteur d'amine humaine et d'un ADN (ARN) codant pour celui-ci, porte également sur la marche à suivre pour le fabriquer par des techniques de recombinaison. Sont également présentées des techniques destinées à la détection d'agonistes et d'antagonistes de ce polypeptide ainsi que des méthodes thérapeutiques faisant appel à ces mêmes agonistes et antagonistes s'agissant du traitement de maladies dues à une sous-expression ou à une sur-expression du transporteur de l'amine humaine relevant de cette invention. Il est, en outre, fait état de procédés permettant de déceler des mutations dans une séquence d'acide nucléique codant pour ce polypeptide ainsi que des modifications de degré de la forme soluble de ce polypeptide.
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