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1. WO1996026955 - PEPTIDE AND A METHOD OF OBTAINING IT

Publication Number WO/1996/026955
Publication Date 06.09.1996
International Application No. PCT/RU1996/000046
International Filing Date 28.02.1996
Chapter 2 Demand Filed 25.09.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
C07K 5/072 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
072the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C07K 5/083 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
083the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/087 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
087the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
C07K 5/09 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
09the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
C07K 5/0205
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
0205containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
C07K 5/021
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
021containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
C07K 5/06104
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06104with the first amino acid being acidic
C07K 5/0804
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
0802with the first amino acid being neutral
0804and aliphatic
Applicants
  • DEIGIN, Vladislav Isakovich [RU]/[RU]
  • KOROTKOV, Andrei Marxovich [RU]/[RU]
Inventors
  • DEIGIN, Vladislav Isakovich
  • KOROTKOV, Andrei Marxovich
Agents
  • ALEXEEVA, Irina Alexeevna
Priority Data
9510246102.03.1995RU
Publication Language Russian (RU)
Filing Language Russian (RU)
Designated States
Title
(EN) PEPTIDE AND A METHOD OF OBTAINING IT
(FR) PEPTIDE ET SON PROCEDE D'OBTENTION
Abstract
(EN)
The invention relates to medicine, specifically, to methods of obtaining biologically active substances with immuno-regulating properties, and can be used in medicine and veterinary science and in experimental biochemistry. The fundamental problem addressed by the invention is that of producing a novel synthetic biologically active peptide with immuno-regulating properties and of the formula: X-Glu-Trp-Y, in which X is H or Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp, $g(g)-aminobutyric acid, $g(z)-aminocaproic acid; Y is Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp, $g(g)-aminobutyric acid, $g(z)- aminocaproic acid, -OH, mono- or di-substituted amide (C1-C3). Peptide synthesis takes place in a solution by successive growth of a chain from the C termination of the molecules, using a strategy of maximum blocking of functional groups, starting from amino acid alkyl ether, using the method of activating the ethers and the method of mixed anhydrides using tributyloxicarbonyl amino acid.
(FR)
L'invention concerne la médecine, spécifiquement des procédés d'obtention de substances biologiquement actives présentant des propriétés immuno-régulatrices, et peut être utilisée en médecine ainsi qu'en science vétérinaire et en biochimie expérimentale. Le problème fondamental abordé par l'invention est celui de la production d'un nouveau peptide synthétique biologiquement actif présentant des propriétés immuno-régulatrices et de la formule: X-Glu-Trp-Y, dans laquelle X représente H ou Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp, acide $g(g)-aminobutyrique, acide $g(z)-aminocaproïque; Y représente Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp, acide $g(g)-aminobutyrique, acide $g(z)-aminocaproïque, -OH, un amide (C1-C3) à mono ou disubstitution. La synthèse du peptide a lieu en solution par la croissance successive d'une chaîne tirée de la terminaison C des molécules, à l'aide d'une stratégie de blocage maximum des groupes fonctionnels, partant d'alkyle éther d'acide aminé, selon le procédé d'activation des éthers et le procédé d'anhydrides mélangés utilisant un acide aminé de tributyloxicarbonyle.
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