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1. WO1996020958 - MONOCLONAL ANTIBODIES SPECIFIC FOR ADVANCED GLYCOSYLATION ENDPRODUCTS IN BIOLOGICAL SAMPLES

Publication Number WO/1996/020958
Publication Date 11.07.1996
International Application No. PCT/US1995/017037
International Filing Date 29.12.1995
Chapter 2 Demand Filed 30.07.1996
IPC
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 16/18 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
C07K 2317/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
24containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Y10S 435/975
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
435Chemistry: molecular biology and microbiology
975Kit
Applicants
  • ALTEON, INC. [US]/[US]
Inventors
  • FOUNDS, Henry, W.
  • SADEGHI, Homayoun
Agents
  • RENDA, Barbara, L.
Priority Data
08/367,50730.12.1994US
08/483,18607.06.1995US
null29.12.1995US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MONOCLONAL ANTIBODIES SPECIFIC FOR ADVANCED GLYCOSYLATION ENDPRODUCTS IN BIOLOGICAL SAMPLES
(FR) ANTICORPS MONOCLONAUX SPECIFIQUES POUR UNE GLYCOSYLATION AVANCEE DE PRODUITS TERMINAUX DANS DES ECHANTILLONS BIOLOGIQUES
Abstract
(EN) The present invention relates to monoclonal antibodies to advanced glycosylation endproducts formed $i(in vivo) and cross-reactive with advanced glycosylation endproducts formed $i(in vitro), and to methods of diagnosis and therapy based thereon. More particularly, the invention is directed to a monoclonal antibody, or an antigen-binding fragment thereof, reactive with $i(in vivo) produced advanced glycosylation endproducts (AGEs), which monoclonal antibody or antigen binding fragment thereof demonstrates an immunological binding characteristic of monoclonal antibodies selected from the group consisting of 4G9 as produced by hybridoma 4G9, deposited with the American Type Culture Collection (ATCC) and assigned Accession Number CRL 11626, 2G6 as produced by hydridoma 2G6, deposited with the American Type Culture Collection (ATCC) on December 19, 1995, and assigned Accession Number HB 12008, and BH4 as produced by hydridoma BH4, deposited with the American Type Culture Collection (ATCC) on December 29, 1995, and assigned Accession Number ZZZ.
(FR) La présente invention concerne des anticorps monoclonaux dirigés contre les produits terminaux de glycosylation avancée obtenus $i(in vivo), et entrant en réaction croisée en présence de produits terminaux de glycosylation avancée formés $i(in vitro). Cette invention concerne également des procédés de diagnostic et de thérapie s'appuyant sur ces éléments. Cette invention concerne plus particulièrement un anticorps monoclonal, ou l'un de ses fragments de liaison à l'antigène, qui réagit en présence de produits terminaux de glycosylation avancée obtenus $i(in vivo) (AGE). Cet anticorps monoclonal, ou l'un de ses fragments de liaison à l'antigène, présente des caractéristiques immunologiques de liaison d'anticorps monoclonaux choisis dans un groupe comportant 4G9 produit à partir de l'hybridome 4G9, déposé auprès de l'American Type Culture Collection (ATCC) sous le numéro d'enregistrement CRL 11626, 2G6 produit à partir de l'hybridome 2G6, déposé auprès de l'ATCC le 19 décembre 1995 sous le numéro d'enregistrement HB 12008, et du BH4 produit à partir de l'hybridome BH4, ces derniers produits ayant été déposés auprès de l'ATCC le 29 décembre 1995 sous le numéro d'enregistrement ZZZ.
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