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1. WO1996019459 - NOVEL SULFONAMIDES

Publication Number WO/1996/019459
Publication Date 27.06.1996
International Application No. PCT/EP1995/004843
International Filing Date 08.12.1995
Chapter 2 Demand Filed 05.07.1996
IPC
C07D 239/69 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
69Benzenesulfonamido-pyrimidines
C07D 401/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
10linked by a carbon chain containing aromatic rings
CPC
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
08Vasodilators for multiple indications
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 9/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
12Antihypertensives
C07D 239/69
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
69Benzenesulfonamido-pyrimidines
C07D 401/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH] (AllExceptUS)
  • BREU, Volker [DE]/[DE] (UsOnly)
  • BURRI, Kaspar [CH]/[CH] (UsOnly)
  • CASSAL, Jean-Marie [FR]/[FR] (UsOnly)
  • CLOZEL, Martine [FR]/[FR] (UsOnly)
  • HIRTH, Georges [FR]/[FR] (UsOnly)
  • LÖFFLER, Bernd-Michael [DE]/[DE] (UsOnly)
  • MÜLLER, Marcel [CH]/[CH] (UsOnly)
  • NEIDHART, Werner [DE]/[FR] (UsOnly)
  • RAMUZ, Henri [CH]/[CH] (UsOnly)
Inventors
  • BREU, Volker
  • BURRI, Kaspar
  • CASSAL, Jean-Marie
  • CLOZEL, Martine
  • HIRTH, Georges
  • LÖFFLER, Bernd-Michael
  • MÜLLER, Marcel
  • NEIDHART, Werner
  • RAMUZ, Henri
Agents
  • GROSSNER, Lutz
Priority Data
2419/95-124.08.1995CH
3837/94-620.12.1994CH
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL SULFONAMIDES
(FR) NOUVEAUX SULFONAMIDES
Abstract
(EN)
Compounds of formula (I) wherein R1-R8, A and B have the significance given in the description, are endothelin inhibitors and can be used for the treatment of disorders which are associated with endothelin activities, such as high blood pressure.
(FR)
Des composés de formule (I), où R1-R8, A et B ont la notation donnée dans le descriptif, sont des inhibiteurs de l'endothéline et peuvent s'utiliser pour le traitement de troubles associés aux activités de l'endothéline, tels que l'hypertension artérielle.
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