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1. WO1996019239 - SOLID COMPOSITION WITH IMPROVED SOLUBILITY AND ABSORBABILITY

Publication Number WO/1996/019239
Publication Date 27.06.1996
International Application No. PCT/JP1995/002611
International Filing Date 20.12.1995
Chapter 2 Demand Filed 08.02.1996
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
CPC
A61K 9/0095
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0087Galenical forms not covered by A61K9/02 - A61K9/7023
0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Applicants
  • YAMANOUCHI PHARMACEUTICAL CO., LTD. [JP]/[JP] (AllExceptUS)
  • YANO, Katsuhiko [JP]/[JP] (UsOnly)
  • KAJIYAMA, Atsushi [JP]/[JP] (UsOnly)
  • YAMAZAKI, Shigeru [JP]/[JP] (UsOnly)
  • ITOH, Naoki [JP]/[JP] (UsOnly)
  • SAKO, Kazuhiro [JP]/[JP] (UsOnly)
Inventors
  • YANO, Katsuhiko
  • KAJIYAMA, Atsushi
  • YAMAZAKI, Shigeru
  • ITOH, Naoki
  • SAKO, Kazuhiro
Agents
  • NAGAI, Shozo
Priority Data
6/31858021.12.1994JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) SOLID COMPOSITION WITH IMPROVED SOLUBILITY AND ABSORBABILITY
(FR) COMPOSITION SOLIDE A SOLUBILITE ET ABSORBABILITE AMELIOREES
Abstract
(EN)
A solid composition with improved solubility and absorbability which comprises an extremely hardly water soluble drug having a solubility of 10 $g(m)g/ml or below and being in the form of an amorphous substance, a polymer base and a nonionic surfactant and, when dispersed in water, forms fine particles having a particule size of 1 $g(m)m or below and containing the extremely hardly water soluble drug sustaining the amorphous form. In the solid composition, the extremely hardly water soluble drug exudes from the fine particles, thus enabling improved absorption of the drug via the digestive tracts.
(FR)
L'invention concerne une composition solide à solubilité et absorbabilité améliorées comprenant un médicament très difficilement soluble dans l'eau, dont la solubilité est inférieure ou égale à 10 $g(m)g/ml et qui se présente sous la forme suivante: substance amorphe, base polymère et tensioactif non ionique. Dispersée dans l'eau, cette composition forme des particules fines de taille inférieure ou égale à 1$g(m)m renfermant le médicament très difficilement soluble dans l'eau qui contient la substance amorphe. Dans ladite composition, le médicament très peu hydrosoluble est exsudé par les fines particules, ce qui améliore l'absorbtion du médicament à l'intérieur du tube digestif.
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