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1. WO1996018730 - PROSTATIC GROWTH FACTOR

Publication Number WO/1996/018730
Publication Date 20.06.1996
International Application No. PCT/US1994/014578
International Filing Date 15.12.1994
Chapter 2 Demand Filed 09.07.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/475 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/475
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
Applicants
  • HUMAN GENOME SCIENCES, INC. [US]/[US] (AllExceptUS)
  • HUDSON, Peter, L. [US]/[US] (UsOnly)
  • ROSEN, Craig, A. [US]/[US] (UsOnly)
  • HE, Wei, Wu [CN]/[US] (UsOnly)
Inventors
  • HUDSON, Peter, L.
  • ROSEN, Craig, A.
  • HE, Wei, Wu
Agents
  • OLSTEIN, Elliot, M.
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROSTATIC GROWTH FACTOR
(FR) FACTEUR DE CROISSANCE PROSTATIQUE
Abstract
(EN)
The present invention relates to human PGF polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptides. Also provided are methods of using the polypeptide therapeutically for treating prostate cancer, to promote tissue regeneration and to facilitate wound healing. Also provided is a diagnostic assay to detect prostate cancer and benign prostatic hyperplasia.
(FR)
L'invention porte sur des polypeptides humains de facteur de croissance prostatique (PGF) et l'ADN codant ces polypeptides. Elle comprend également une procédure de production de ces polypeptides utilisant des techniques de recombinaison, des anticorps et des antagonistes/inhibiteurs de ces polypeptides. Elle comprend également des procédés d'utilisation des polypeptides à des fins thérapeutiques pour traiter le cancer de la prostate, favoriser la regénérescence tissulaire et améliorer la cicatrisation. Elle comprend également une méthode diagnostique qui permet de détecter le cancer de la prostate et l'hyperplasie prostatique bénigne.
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