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1. WO1996018115 - FLUORESCENCE DETECTION APPARATUS

Publication Number WO/1996/018115
Publication Date 13.06.1996
International Application No. PCT/US1995/015910
International Filing Date 06.12.1995
Chapter 2 Demand Filed 27.06.1996
IPC
C12M 1/34 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
34Measuring or testing with condition measuring or sensing means, e.g. colony counters
G01N 21/25 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
G01N 21/64 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
G01N 33/15 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15Medicinal preparations
G01N 35/00 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/-G01N33/148; Handling materials therefor
G01T 7/02 2006.01
GPHYSICS
01MEASURING; TESTING
TMEASUREMENT OF NUCLEAR OR X-RADIATION
7Details of radiation-measuring instruments
02Collecting-means for receiving or storing samples to be investigated
CPC
C12M 41/46
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
41Means for regulation, monitoring, measurement or control, e.g. flow regulation
46of cellular or enzymatic activity or functionality, e.g. cell viability
G01N 2021/6463
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
645Specially adapted constructive features of fluorimeters
6463Optics
G01N 2021/6484
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
645Specially adapted constructive features of fluorimeters
6484Optical fibres
G01N 2021/6493
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
6491Measuring fluorescence and transmission; Correcting inner filter effect
6493by alternating fluorescence/transmission or fluorescence/reflection
G01N 21/251
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
251Colorimeters; Construction thereof
G01N 21/645
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
645Specially adapted constructive features of fluorimeters
Applicants
  • NPS PHARMACEUTICALS, INC. [US]/[US]
Inventors
  • HAROOTUNIAN, Alec, T.
Agents
  • WITT, Evan, R.
Priority Data
08/350,23206.12.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FLUORESCENCE DETECTION APPARATUS
(FR) APPAREIL DE DETECTION DE FLUORESCENCE
Abstract
(EN)
A fluorescence analysis system detects light transmitted from wells in a sample plate. One embodiment of the system includes a single light detector. A reflector is capable of receiving light from any one of several detection emitters and of reflecting the light toward the light detector. One reflector includes a prism which is mounted on a stepping motor. The prism is selectively rotated so that it faces each detection emitter in turn. The light from several wells in a row is directed toward the light emitter by rotating the prism to face, one-by-one, each of the emitters corresponding to the wells. The detection emitters include one end of an optical fiber bundle. The other end of each bundle is positioned near the wells, with each bundle positioned by a different well to carry light from that well to the corresponding emitter. A collimating lens is positioned between each detection emitter and the rotating prism to focus light from the emitter onto the prism. A baffle is positioned between the light detector and the prism. Light from a xenon arc excitation lamp is carried by optical fiber bundles toward the sample wells. A computerized controller coordinates light detection with the activities of an automated liquid handling system.
(FR)
Cette invention concerne un système d'analyse de fluorescence détectant la lumière émise par des puits disposés sur une plaque d'échantillonnage. Dans un des modes de réalisation, ce système comporte un seul détecteur de lumière. Un réflecteur, recevant la lumière de l'un des émetteurs de détection quel qu'il soit, la renvoie vers le détecteur de lumière. Un réflecteur se compose d'un prisme monté sur un moteur pas-à-pas et qui tourne de manière sélective afin de faire face tour à tour à chacun des émetterus de détection. La lumière provenant simultanément de plusieurs puits dans une rangée est dirigée vers l'émetteur de lumière par rotation du prisme qui fait face, tour à tour, à chacun des émetteurs correspondant aux puits. Chaque émetteur de détection comporte une extrémité d'un faisceau de fibres optiques. L'autre extrémité de chaque faisceau se trouve près des puits de manière à ce que chaque faisceau placé à proximité d'un puits donné transporte la lumière de ce puits jusqu'à l'émetteur correspondant. Une lentille collimatrice est placée entre chaque émetteur de détection et le prisme rotatif afin de concentrer la lumière provenant de l'émetteur sur ledit prisme. Une chicane est également disposée entre le détecteur de lumière et le prisme. La lumière émise par une lampe à arc à xénon est transportée par des faisceaux de fibres optiques jusqu'aux puits d'échantillonnage. Une unité de contrôle informatisée coordonne la détection de lumière et le fonctionnement d'un système automatisé de manipulation des liquides.
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