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1. WO1996017078 - ANTITHROMBOTIC AGENT AND ANTI-VON WILLEBRAND FACTOR MONOCLONAL ANTIBODIES

Publication Number WO/1996/017078
Publication Date 06.06.1996
International Application No. PCT/JP1995/002435
International Filing Date 29.11.1995
Chapter 2 Demand Filed 25.03.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 16/36 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
36against blood coagulation factors
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
C07K 16/36
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
36against blood coagulation factors
Applicants
  • AJINOMOTO CO., INC. [JP]/[JP] (AllExceptUS)
  • NAGANO, Mitsuyo [JP]/[JP] (UsOnly)
  • YAMAMOTO, Hiroshi [JP]/[JP] (UsOnly)
  • KITO, Morikazu [JP]/[JP] (UsOnly)
  • YOSHIMOTO, Ryota [JP]/[JP] (UsOnly)
  • KOBAYASHI, Tsuyoshi [JP]/[JP] (UsOnly)
Inventors
  • NAGANO, Mitsuyo
  • YAMAMOTO, Hiroshi
  • KITO, Morikazu
  • YOSHIMOTO, Ryota
  • KOBAYASHI, Tsuyoshi
Agents
  • TOYAMA, Tsutomu
Priority Data
6/29707030.11.1994JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) ANTITHROMBOTIC AGENT AND ANTI-VON WILLEBRAND FACTOR MONOCLONAL ANTIBODIES
(FR) AGENT ANTITHROMBOTIQUE ET ANTICORPS MONOCLONAUX CONTRE LE FACTEUR DE VON WILLEBRAND
Abstract
(EN)
An antithrombotic agent containing as the active ingredient a monoclonal antibody that is reactive with human Von Willebrand factor, inhibits human RIPA (ristocetin-induced platelet aggregation), BIPA (bottrocetin-induced platelet aggregation), and SIPA (stress-induced platelet aggregation), and does not cause bleeding even when it is administered in a quantity efficacious in exhibiting the antithrombotic effect.
(FR)
Cette invention se rapporte à un agent antithrombotique contenant comme ingrédient actif un anticorps monoclonal qui réagit avec le facteur de von Willebrand humain qui inhibe l'agrégation plaquettaire induite par ristocétine (APIR), l'agrégation plaquettaire induite par bottrocétine (APIB) et l'agrégation plaquettaire induite par le stress (APIS), et qui ne cause pas de saignement, même lorsqu'il est administré en quantité propre à produire l'effet antithrombotique.
Also published as
FI972279
NO19972253
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