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1. WO1996010012 - NOVEL PROSTAGLANDIN SYNTHASE INHIBITORS

Publication Number WO/1996/010012
Publication Date 04.04.1996
International Application No. PCT/US1995/012225
International Filing Date 26.09.1995
Chapter 2 Demand Filed 18.03.1996
IPC
C07C 311/15 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
311Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
C07C 317/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
14having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
C07C 317/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
16having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
22with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
C07C 317/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
24having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
C07C 317/36 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
26having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
32with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
34having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
36with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
C07D 207/33 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30having two double bonds between ring members or between ring members and non-ring members
32with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
33with substituted hydrocarbon radicals, directly attached to ring carbon atoms
CPC
A61P 25/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07C 2601/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
12with a six-membered ring
14The ring being saturated
C07C 311/15
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
311Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
C07C 317/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
14having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
Applicants
  • THE DU PONT MERCK PHARMACEUTICAL COMPANY [US]/[US] (AllExceptUS)
  • BATT, Douglas, Guy [US]/[US] (UsOnly)
  • PINTO, Donald, Joseph, Phillip [US]/[US] (UsOnly)
  • ORWAT, Michael, James [US]/[US] (UsOnly)
  • PETRAITIS, Joseph, James [US]/[US] (UsOnly)
  • PITTS, William, John [US]/[US] (UsOnly)
Inventors
  • BATT, Douglas, Guy
  • PINTO, Donald, Joseph, Phillip
  • ORWAT, Michael, James
  • PETRAITIS, Joseph, James
  • PITTS, William, John
Agents
  • KONDRAD, Karen, H.
Priority Data
08/314,99129.09.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL PROSTAGLANDIN SYNTHASE INHIBITORS
(FR) NOUVEAUX INHIBITEURS DE LA PROSTAGLANDINE-SYNTHASE
Abstract
(EN)
This invention relates to ortho substituted phenyl compounds as inhibitors of prostaglandin synthase, to pharmaceutical compositions comprising such compounds and to methods of using such compounds as antiinflammatory and antipyretic agents. The class of compounds useful in this method of treatment is represented by formula (I).
(FR)
L'invention porte sur des composés phényliques orthosubstitués inhibiteurs de la prostaglandine-synthase, sur des préparations pharmaceutiques contenant lesdits composés et sur leur mode d'utilisation comme agents anti-inflammatoires et antipyrétiques. La catégorie des composés utilisés dans cette méthode de traitement est représentée par la formule (I).
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