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Machine translation
1. (WO1996008487) ENDOTHELIN ANTAGONISTS BEARING PYRIDYL AMIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/008487    International Application No.:    PCT/US1995/011485
Publication Date: 21.03.1996 International Filing Date: 11.09.1995
Chapter 2 Demand Filed:    08.04.1996    
IPC:
A61K 45/06 (2006.01), C07D 405/12 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, NJ 07065 (US) (For All Designated States Except US).
ASHTON, Wallace, T. [US/US]; (US) (For US Only).
CHANG, Linda, L. [CA/US]; (US) (For US Only).
GREENLEE, William, J. [US/US]; (US) (For US Only)
Inventors: ASHTON, Wallace, T.; (US).
CHANG, Linda, L.; (US).
GREENLEE, William, J.; (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, NJ 07065 (US)
Priority Data:
306,271 14.09.1994 US
Title (EN) ENDOTHELIN ANTAGONISTS BEARING PYRIDYL AMIDES
(FR) ANTAGONISTES DE L'ENDOTHELINE PORTEURS D'AMIDES PYRIDYLIQUES
Abstract: front page image
(EN)Phenoxyphenylacetic acids and derivatives of general structural formula (I) have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.
(FR)Les acides phénoxyphénylacétiques et leurs dérivés de la formule de structure génerale (I) exerçent une activité antagoniste de l'endothéline et se revèlent utiles dans le traitement de troubles cardio-vasculaires, comme l'hypertension, de l'insuffisance rénale post-ischémique, du vasospasme, de l'ischémie cérébrale et cardiaque, de l'infarctus du myocarde, du choc endotoxique, de l'hyperplasie bénigne de la prostate, de maladies inflammatoires dont le syndrome de Raynaud et de l'asthme.
Designated States: AM, AU, BB, BG, BR, BY, CA, CN, CZ, EE, FI, GE, HU, IS, JP, KG, KR, KZ, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TJ, TM, TT, UA, US, UZ.
African Regional Intellectual Property Organization (KE, MW, SD, SZ, UG)
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)