WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO1996008268) INHIBITION OF ENDOTHELIN-1 TO REDUCE INFLAMMATORY PROCESSES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/008268    International Application No.:    PCT/US1995/011937
Publication Date: 21.03.1996 International Filing Date: 12.09.1995
Chapter 2 Demand Filed:    11.04.1996    
IPC:
A61K 38/00 (2006.01), A61K 38/22 (2006.01), A61K 48/00 (2006.01), C07K 14/575 (2006.01), C07K 14/72 (2006.01), C07K 16/28 (2006.01)
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street, Cambridge, MA 02139 (US).
BRIGHAM & WOMEN'S HOSPITAL [US/US]; 75 Francis Street, Boston, MA 02115 (US)
Inventors: RUSSELL, Mary, E.; (US).
SAYEGH, Mohamed; (US).
WATSCHINGER, Bruno; (AT)
Agent: FRASER, Janis, K.; Fish & Richardson P.C., 225 Franklin Street, Boston, MA 02110-2804 (US)
Priority Data:
08/307,354 14.09.1994 US
Title (EN) INHIBITION OF ENDOTHELIN-1 TO REDUCE INFLAMMATORY PROCESSES
(FR) INHIBITION DE L'ENDOTHELINE-1 POUR COMBATTRE LES INFLAMMATIONS
Abstract: front page image
(EN)The vasoactive and mitogenic peptide, endothelin-1 (ET-1) is upregulated within grafts, and methods of diagnosing and treating graft rejection, arteriosclerosis, and other cell-mediated inflammatory conditions are provided. These methods involve identifying and reducing expression of ET-1.
(FR)La production du peptide vasoactif et mitogène qu'est l'endothéline-1 (ET-1) est stimulée dans les greffes. L'invention concerne des procédés pour diagnostiquer et traiter les rejets de greffes, l'artériosclérose et d'autres inflammations à médiateurs cellulaires. Ces procédés consistent à déterminer le niveau d'expression de l'ET-1, et à le réduire.
Designated States: CA, JP.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)