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Machine translation
1. (WO1996007663) SOLID PHASE SYNTHESIS OF OLIGONUCLEOTIDES WITH STEREOSPECIFIC SUBSTITUTED PHOSPHONATE LINKAGES BY PENTAVALENT GRIGNARD COUPLING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/007663    International Application No.:    PCT/US1995/010866
Publication Date: 14.03.1996 International Filing Date: 28.08.1995
Chapter 2 Demand Filed:    02.02.1996    
IPC:
C07H 21/00 (2006.01)
Applicants: THOMAS JEFFERSON UNIVERSITY [US/US]; 1020 Locust Street, Philadelphia, PA 19107 (US)
Inventors: WICKSTROM, Eric; (US).
LE BEC, Christine; (FR)
Agent: MONACO, Daniel, A.; Seidel, Gonda, Lavorgna & Monaco, P.C., Suite 1800, Two Penn Center Plaza, Philadelphia, PA 19102 (US)
Priority Data:
300,259 02.09.1994 US
Title (EN) SOLID PHASE SYNTHESIS OF OLIGONUCLEOTIDES WITH STEREOSPECIFIC SUBSTITUTED PHOSPHONATE LINKAGES BY PENTAVALENT GRIGNARD COUPLING
(FR) SYNTHESE EN PHASE SOLIDE D'OLIGONUCLEOTIDES A LIAISONS STEREOSPECIFIQUES PHOSPHONATE SUBSTITUEES PAR COUPLAGE PENTAVALENT DE GRIGNARD
Abstract: front page image
(EN)The present invention provides a method for producing an oligonucleotide having stereospecific substituted phosphonate linkages by use of a pentavalent Grignard coupling reaction on a solid phase support. The method can be used for automated synthesis of oligonucleotides having sequential equatorial or axial stereospecific substituted phosphonate linkages.
(FR)Procédé de production d'un oligonucléotide à liaisons stéréospécifiques phosphonate substituées qui consiste à utiliser la réaction de couplage pentavalent de Grignard sur un support en phase solide. Ce procédé peut être appliqué pour la synthèse automatisée d'oligonucléotides présentant des liaisons phosphonate substituées stéréospécifiques séquentielles, équatoriales ou axiales.
Designated States: CA, JP.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)