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1. (WO1996006837) ISOXAZOLES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/006837    International Application No.:    PCT/JP1995/001714
Publication Date: 07.03.1996 International Filing Date: 29.08.1995
Chapter 2 Demand Filed:    29.08.1995    
IPC:
C07D 261/20 (2006.01), C07D 498/04 (2006.01)
Applicants: SANKYO COMPANY, LIMITED [JP/JP]; 5-1, Nihonbashi Honcho 3-chome, Chuo-ku, Tokyo 103 (JP) (For All Designated States Except US).
KOJIMA, Koichi [JP/JP]; (JP) (For US Only).
AIZAWA, Yuichi [JP/JP]; (JP) (For US Only).
KANEKO, Isao [JP/JP]; (JP) (For US Only).
SAKAI, Junichi [JP/JP]; (JP) (For US Only).
KOZUKA, Masao [JP/JP]; (JP) (For US Only).
KOYAMA, Kazuo [JP/JP]; (JP) (For US Only).
SAMATA, Naozumi [JP/JP]; (JP) (For US Only).
YOSHIMI, Kenji [JP/JP]; (JP) (For US Only)
Inventors: KOJIMA, Koichi; (JP).
AIZAWA, Yuichi; (JP).
KANEKO, Isao; (JP).
SAKAI, Junichi; (JP).
KOZUKA, Masao; (JP).
KOYAMA, Kazuo; (JP).
SAMATA, Naozumi; (JP).
YOSHIMI, Kenji; (JP)
Agent: NAKAMURA, Minoru; Room 646, Shin-Tokyo Building, 3-1, Marunouchi 3-chome, Chiyoda-ku, Tokyo 100 (JP)
Priority Data:
6/205363 30.08.1994 JP
7/150571 16.06.1995 JP
Title (EN) ISOXAZOLES
(FR) ISOXAZOLES
Abstract: front page image
(EN)An isoxazole derivative represented by general formula (I), having an excellent monoamine oxidase inhibitory activity, and being useful as a remedy or preventive for nervous diseases such as Parkinson's diseases, wherein R?1¿ represents hydrogen, halogen, alkyl, alkoxy, hydroxy, alkylthio, amino, alkanoyl, alkanoylamino, alkanoyloxy, alkoxycarbonyl, carboxy, (alkylthio)-thiocarbonyl, carbamoyl, nitro or cyano; R?2¿ represents amino; m represents an integer of 1 to 3; n represents an integer of 1 to 6; ring A represents benzene, naphthalene or aromatic heterocycle; and X represents oxygen or sulfur.
(FR)L'invention concerne un dérivé isoxazole représenté par la formule générale (I) qui présente une excellente activité inhibitrice vis-à-vis de la monoamine oxydase et qui est utile comme médicament préventif ou curatif contre des maladies nerveuses, telles que la maladie de Parkinson. Dans la formule (I), R?1¿ représente un hydrogène, un halogène, un groupe alkyle, alcoxy, hydroxy, alkylthio, amino, alcanoyle, alcanoylamino, alcanoyloxy, alcoxycarbonyle, carboxy, (alkylthio)thiocarbonyle, carbamoyle, nitro ou cyano; R?2¿ représente un amino; m représente un nombre entier entre 1 et 3; n représente un nombre entier entre 1 et 6; le cycle A représente un benzène, un naphtalène ou un hétérocycle aromatique; et X représente oxygène ou soufre.
Designated States: AU, CA, CN, CZ, FI, HU, KR, MX, NO, NZ, RU, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)