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1. (WO1996006825) GUANIDINOMETHYL CYCLOHEXANE CARBOXYLIC ESTER DERIVATIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/006825    International Application No.:    PCT/JP1995/001725
Publication Date: 07.03.1996 International Filing Date: 30.08.1995
Chapter 2 Demand Filed:    28.03.1996    
IPC:
A61K 31/215 (2006.01), A61K 31/24 (2006.01), C07C 279/14 (2006.01)
Applicants: TEIKOKU CHEMICAL INDUSTRIES CO., LTD. [JP/JP]; 1-18, Kitahorie 1-chome, Nishi-ku, Osaka-shi, Osaka 550 (JP) (For All Designated States Except US).
KAMODA, Osamu [JP/JP]; (JP) (For US Only).
FUJIWARA, Hiromichi [JP/JP]; (JP) (For US Only).
YANAGI, Toshiharu [JP/JP]; (JP) (For US Only)
Inventors: KAMODA, Osamu; (JP).
FUJIWARA, Hiromichi; (JP).
YANAGI, Toshiharu; (JP)
Agent: SAEKI, Norio; 2nd-Tsutiya Building 9F, 30-9, Taito 1-chome, Taito-ku, Tokyo 110 (JP)
Priority Data:
6/243489 30.08.1994 JP
6/243490 30.08.1994 JP
6/248270 05.09.1994 JP
6/252655 09.09.1994 JP
Title (EN) GUANIDINOMETHYL CYCLOHEXANE CARBOXYLIC ESTER DERIVATIVE
(FR) DERIVE ESTER DE L'ACIDE GUANIDINOMETHYLCYCLOHEXANECARBOXYLIQUE
Abstract: front page image
(EN)A compound represented by general formula (I-2) or a pharmaceutically acceptable acid-addition salt thereof, useful as an anti-microbial against $i(Helicobacter pylori) and as a medicinal composition for treating $i(Helicobacter pylori) infection, wherein Ar represents phenyl, biphenyl or naphthyl each having at leat one substituent selected from the group consisting of halogeno, cyano, nitro, carboxy, C¿1?-C¿18? alkyl, C¿1?-C¿18? alkoxy, C¿3?-C¿18? cycloalkyl, C¿7?-C¿18? aralkyl, C¿8?-C¿18? arylalkenyl, C¿7?-C¿18? aralkyloxy, optionally substituted phenoxy, optionally substituted C¿2?-C¿19? alkoxycarbonyl, and optionally substituted C¿8?-C¿19? aralkyloxycarbonyl, provided the case where Ar represents phenyl substituted by halogeno, cyano, nitro, carboxy, C¿1?-C¿18? alkyl, optionally substituted C¿2?-C¿19? alkoxycarbonyl or C¿8?-C¿19? aralkyloxycarbonyl is expected.
(FR)Composé de formule générale (I-2) ou l'un de ses sels d'addition d'acide pharmacocompatible utilisable comme agent antimicrobien pour le traitement de l'$i(Helicobacter pylori) et comme préparation médicinale pour ledit traitement. Dans ladite formule, Ar représente phényle, biphényle, ou naphtyle avec chacun au moins un substituant choisi parmi halogéno, cyano, nitro, carboxy, C¿1?-C¿18? alkyle, C¿1?-C¿18? alcoxy, C¿3?-C¿18? cycloalkyle, C¿7?-C¿18? aralkyle, C¿8?-C¿18? arylalcényle, C¿7?-C¿18? aralkyloxy, phénoxy facultativement substitué, C¿2?-C¿19? alcoxycarbonyle facultativement substitué, C¿8?-C¿19? aralkyloxycarbonyle facultativement substitué, sous réserve que le cas où Ar représente phényle substitué par halogéno, cyano, nitro, carboxy, C¿1?-C¿18? alkyle, C¿2?-C¿19? alcoxycarbonyle, ou C¿8?-C¿19? aralkyloxycarbonyle soit prévu.
Designated States: JP, KR, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)