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Machine translation
1. (WO1996006616) QUINAZOLINONE PHARMACEUTICALS AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/006616    International Application No.:    PCT/US1995/011186
Publication Date: 07.03.1996 International Filing Date: 29.08.1995
Chapter 2 Demand Filed:    21.03.1996    
IPC:
A61K 31/517 (2006.01)
Applicants: DAVIDSON, Clifford, M. [US/US]; (US) (For All Designated States Except US).
AGRICULTURAL RESEARCH ORGANIZATION, MINISTRY OF AGRICULTURAL, STATE OF ISRAEL [IL/IL]; The Volcani Center, 50250 Bet Dagan (IL) (For All Designated States Except US).
HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT COMPANY LTD., KIRYAT HADASSAH [IL/IL]; The Volcani Center, 50250 Bet Dagan (IL) (For All Designated States Except US).
NAGLER, Arnon [IL/IL]; (IL) (For US Only).
SLAVIN, Shimon [IL/IL]; (IL) (For US Only).
VLODAVSKY, Israel [IL/IL]; (IL) (For US Only).
PINES, Mark [IL/IL]; (IL) (For US Only)
Inventors: NAGLER, Arnon; (IL).
SLAVIN, Shimon; (IL).
VLODAVSKY, Israel; (IL).
PINES, Mark; (IL)
Agent: RASKIN, Martin, G.; Steinberg, Raskin & Davidson, P.C., 1140 Avenue of the Americas, New York, NY 10036 (US)
Priority Data:
110831 31.08.1994 IL
Title (EN) QUINAZOLINONE PHARMACEUTICALS AND USE THEREOF
(FR) COMPOSITIONS PHARMACEUTIQUES A BASE DE QUINAZOLINONE ET LEUR UTILISATION
Abstract: front page image
(EN)The invention provides a pharmaceutical composition for preventing restenosis by the inhibition of vascular smooth muscle cell proliferation, comprising a compound of formula (I) wherein: R¿1? is a member of the group consisting of hydrogen, halogen, nitro, benzo, lower alkyl, phenyl and lower alkoxy; R¿2? is a member of the group consisting of hydroxy, acetoxy, and lower alkoxy, and R¿3? is a member of the group consisting of hydrogen and lower alkenoxy-carbonyl as active ingredient therein, in combination with a pharmaceutically acceptable carrier.
(FR)L'invention concerne une composition pharmaceutique conçue pour empêcher la resténose par inhibition de la prolifération des cellules des muscles lisses, qui comprend un composé de la formule (I) dans lequel: R¿1? est un membre du groupe constitué d'hydrogène, halogène, nitro, benzo, alkyle inférieur, phényl et alcoxyle inférieur; R¿2? est un membre du groupe constitué d'hydroxy, acétoxy, et alcoxyle inférieur, et R¿3? est un membre du groupe constitué d'hydrogène et d'alkénoxy-carbonyle inférieur agissant comme principe actif en association avec un véhicule acceptable sur le plan pharmaceutique.
Designated States: AM, AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (KE, MW, SD, SZ, UG)
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)