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Pub. No.:    WO/1996/006606    International Application No.:    PCT/US1995/010945
Publication Date: 07.03.1996 International Filing Date: 30.08.1995
Chapter 2 Demand Filed:    29.02.1996    
C07D 317/58 (2006.01), C07D 491/04 (2006.01), C07D 493/04 (2006.01)
Applicants: ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center, Indianapolis, IN 46285 (US) (For All Designated States Except US).
ANDERSON, Benjamin, Alan [US/US]; (US) (For US Only).
HANSEN, Marvin, Martin [US/US]; (US) (For US Only).
HARN, Nancy, Kay [US/US]; (US) (For US Only)
Inventors: ANDERSON, Benjamin, Alan; (US).
HANSEN, Marvin, Martin; (US).
HARN, Nancy, Kay; (US)
Agent: LAMMERT, Steven, R.; Barnes & Thornburg, 1313 Merchants Bank Building, 11 South Meridian Street, Indianapolis, IN 46204 (US)
Priority Data:
08/298,645 31.08.1994 US
08/413,029 28.03.1995 US
Abstract: front page image
(EN)Compounds having general formula (I) wherein R is hydrogen or C¿1?-C¿10? alkyl; X is an aromatic moiety selected from phenyl, thienyl, furyl, pyridyl, imidazolyl, benzimidazolyl, benzothiazolyl and phthalazinyl which is unsubstituted or substituted with one or more moieties chosen from the group consisting of halogen, hydroxy, cyano, nitro, C¿1?-C¿6? alkyl, C¿3?-C¿6? cycloalkyl, C¿1?-C¿4? alkoxy, carboxy, C¿1?-C¿6? alkoxycarbonyl, acetyl, formyl, carboxymethyl, hydroxymethyl, amino, aminomethyl, methylenedioxy and trifluoromethyl; and 'Aryl' represents p-nitrophenyl, p-aminophenyl or p-(protected amino) phenyl; or a pharmaceutically acceptable salt thereof, are useful as anticonvulsants.
(FR)Composés de formule générale (I) dans laquelle R est hydrogène ou alkyle C¿1?-C¿10?; X est une fraction aromatique sélectionnée parmi phényle, thiényle, furyle, pyridyle, imidazolyle, benzimidazolyle, benzothiazolyle et phtalazinyle qui est non substitué ou substitué avec une ou plusieurs fractions choisies dans le groupe composé d'halogène, hydroxy, cyano, nitro, alkyle C¿1?-C¿6?, cycloalkyle C¿3?-C¿6?, alcoxy C¿1?-C¿4?, carboxy, alcoxycarbonyle C¿1?-C¿6?, acétyle, formyle, carboxyméthyle, hydroxyméthyle, amino, aminométhyle, méthylènedioxy et trifluorométhyle; et 'aryle' représente p-nitrophényle, p-aminophényle ou p-(amino protégé)phényle. Ces composés, ou un de leurs sels acceptable en pharmacologie, sont utiles comme agents anticonvulsifs.
Designated States: AM, AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (KE, MW, SD, SZ, UG)
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)