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1. WO1996006181 - METHOD OF MODIFYING PROTEIN

Publication Number WO/1996/006181
Publication Date 29.02.1996
International Application No. PCT/JP1995/000298
International Filing Date 27.02.1995
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/55 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins (IL)
55IL-2
C12P 21/02 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
02having a known sequence of two or more amino acids, e.g. glutathione
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/55
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins [IL]
55IL-2
C12P 21/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
02having a known sequence of two or more amino acids, e.g. glutathione
Applicants
  • DRUG DELIVERY SYSTEM INSTITUTE, LTD. [JP/JP]; 17-5, Shibuya 2-chome Shibuya-ku Tokyo 150, JP (AllExceptUS)
  • SATO, Haruya [JP/JP]; JP (UsOnly)
  • YAMAMOTO, Keiji [JP/JP]; JP (UsOnly)
  • SUZUKI, Kokichi [JP/JP]; JP (UsOnly)
  • IKEDA, Masahiro [JP/JP]; JP (UsOnly)
  • SAKAGAMI, Masahiro [JP/JP]; JP (UsOnly)
  • TANIGUCHI, Makoto [JP/JP]; JP (UsOnly)
Inventors
  • SATO, Haruya; JP
  • YAMAMOTO, Keiji; JP
  • SUZUKI, Kokichi; JP
  • IKEDA, Masahiro; JP
  • SAKAGAMI, Masahiro; JP
  • TANIGUCHI, Makoto; JP
Agents
  • KAWAGUCHI, Yoshio ; Yamada Building 1-14, Shinjuku 1-chome Shinjuku-ku Tokyo 160, JP
Priority Data
6/19818723.08.1994JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD OF MODIFYING PROTEIN
(FR) PROCEDE DE MODIFICATION DE PROTEINE
Abstract
(EN)
A physiologically active protein (including a fused protein comprising the same and a peptide bonded thereto through an amide linkage) is improved in the adaptability to a medicine by modifying the protein through the action of a transglutaminase on the same and an amino group donor having a polyethylene glycol, polysaccharide, polyamino acid or branched saccharide derivative portion without detriment to the inherent physiological activity.
(FR)
On améliore la possibilité d'adaptation en médicament d'une protéine physiologiquement active (incluant une protéine fusionnée renfermant celle-ci et un peptide lié à celle-ci par une liaison amide) en modifiant la protéine par l'action de la transglutaminase sur la protéine et d'un donneur de groupe amino comportant une partie dérivée de polyéthylène glycol, polysaccharide, acide polyaminé ou saccharide ramifié, sans causer d'altération à son activité physiologique intrinsèque.
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