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Machine translation
1. (WO1996006181) METHOD OF MODIFYING PROTEIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/006181    International Application No.:    PCT/JP1995/000298
Publication Date: 29.02.1996 International Filing Date: 27.02.1995
IPC:
A61K 38/00 (2006.01), C07K 14/55 (2006.01), C12P 21/02 (2006.01)
Applicants: DRUG DELIVERY SYSTEM INSTITUTE, LTD. [JP/JP]; 17-5, Shibuya 2-chome, Shibuya-ku, Tokyo 150 (JP) (For All Designated States Except US).
SATO, Haruya [JP/JP]; (JP) (For US Only).
YAMAMOTO, Keiji [JP/JP]; (JP) (For US Only).
SUZUKI, Kokichi [JP/JP]; (JP) (For US Only).
IKEDA, Masahiro [JP/JP]; (JP) (For US Only).
SAKAGAMI, Masahiro [JP/JP]; (JP) (For US Only).
TANIGUCHI, Makoto [JP/JP]; (JP) (For US Only)
Inventors: SATO, Haruya; (JP).
YAMAMOTO, Keiji; (JP).
SUZUKI, Kokichi; (JP).
IKEDA, Masahiro; (JP).
SAKAGAMI, Masahiro; (JP).
TANIGUCHI, Makoto; (JP)
Agent: KAWAGUCHI, Yoshio; Yamada Building, 1-14, Shinjuku 1-chome, Shinjuku-ku, Tokyo 160 (JP)
Priority Data:
6/198187 23.08.1994 JP
Title (EN) METHOD OF MODIFYING PROTEIN
(FR) PROCEDE DE MODIFICATION DE PROTEINE
Abstract: front page image
(EN)A physiologically active protein (including a fused protein comprising the same and a peptide bonded thereto through an amide linkage) is improved in the adaptability to a medicine by modifying the protein through the action of a transglutaminase on the same and an amino group donor having a polyethylene glycol, polysaccharide, polyamino acid or branched saccharide derivative portion without detriment to the inherent physiological activity.
(FR)On améliore la possibilité d'adaptation en médicament d'une protéine physiologiquement active (incluant une protéine fusionnée renfermant celle-ci et un peptide lié à celle-ci par une liaison amide) en modifiant la protéine par l'action de la transglutaminase sur la protéine et d'un donneur de groupe amino comportant une partie dérivée de polyéthylène glycol, polysaccharide, acide polyaminé ou saccharide ramifié, sans causer d'altération à son activité physiologique intrinsèque.
Designated States: CA, DE, JP, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)