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Machine translation
1. (WO1996006177) RETROVIRUS-LIKE PARTICLES MADE NON-INFECTIOUS BY A PLURALITY OF MUTATIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/006177    International Application No.:    PCT/CA1995/000489
Publication Date: 29.02.1996 International Filing Date: 22.08.1995
Chapter 2 Demand Filed:    25.01.1996    
IPC:
A61K 39/00 (2006.01), A61K 48/00 (2006.01), C07K 14/08 (2006.01), C07K 14/16 (2006.01), C12N 7/04 (2006.01), C12N 15/867 (2006.01)
Applicants: CONNAUGHT LABORATORIES LIMITED [CA/CA]; 1755 Steeles Avenue West, Willowdale, Ontario M2R 3T4 (CA) (For All Designated States Except US).
ROVINSKI, Benjamin [CA/CA]; (CA) (For US Only).
CAO, Shi-Xian [CA/CA]; (CA) (For US Only).
YAO, Fei-Long [CN/CA]; (CA) (For US Only).
PERSSON, Roy [CA/CA]; (CA) (For US Only).
KLEIN, Michel, H. [CA/CA]; (CA) (For US Only)
Inventors: ROVINSKI, Benjamin; (CA).
CAO, Shi-Xian; (CA).
YAO, Fei-Long; (CA).
PERSSON, Roy; (CA).
KLEIN, Michel, H.; (CA)
Agent: STEWART, Michael, I.; Sim & McBurney, Suite 701, 330 University Avenue, Toronto, Ontario M5G 1R7 (CA)
Priority Data:
08/292,967 22.08.1994 US
Title (EN) RETROVIRUS-LIKE PARTICLES MADE NON-INFECTIOUS BY A PLURALITY OF MUTATIONS
(FR) PARTICULES SEMBLABLES A DES RETROVIRUS RENDUES NON-INFECTIEUSES PAR UNE PLURALITE DE MUTATIONS
Abstract: front page image
(EN)Non-infectious, retrovirus-like particles contain mutations to reduce gag-dependent RNA-packaging of the gag gene product, eliminate reverse transcriptase activity of the pol gene product, eliminate integrase activity of the pol gene product and eliminate RNase H activity of the pol gene product through genetic manipulation of the gag and pol genes. The corresponding nucleic acid molecules are described. The non-infectious, retrovirus-like particles have utility in $i(in vivo) administration including to humans and in diagnosis.
(FR)Des particules non-infectieuses semblables à des rétrovirus contiennent des mutations destinées à réduire pour un produit génique, gag, l'enroulement de l'ARN dépendant de gag, et pour éliminer les activités transcriptase inverse, intégrase, et RNase H du produit génique pol par manipulation génétique des gènes gag et pol. On décrit les molécules d'acide nucléique correspondantes. Ces particules non-infectieuses semblables à des rétrovirus présentent une utilité pour l'administration $i(in vivo), y compris chez l'être humain, et pour des diagnostics.
Designated States: AM, AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LT, LU, LV, MD, MG, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (KE, MW, SD, SZ, UG)
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)