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1. WO1996006169 - HUMAN CHEMOKINE BETA-9

Publication Number WO/1996/006169
Publication Date 29.02.1996
International Application No. PCT/US1995/006260
International Filing Date 06.06.1995
Chapter 2 Demand Filed 28.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/52 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
02for treating wounds, ulcers, burns, scars, keloids, or the like
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
Applicants
  • HUMAN GENOME SCIENCES, INC. [US/US]; 9410 Key West Avenue Rockville, MD 20850-3338, US (AM, AT, AU, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CZ, DE, DK, ES, FI, FR, GA, GB, GE, GN, GR, HU, IE, IT, JP, KE, KG, KP, KR, KZ, LK, LT, LU, LV, MC, MD, MG, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SI, SK, SN, SZ, TD, TG, TJ, TT, UA, UG, UZ, VN)
  • LI, Haodong [--/US]; US (UsOnly)
  • ADAMS, Mark, D. [--/US]; US (UsOnly)
Inventors
  • LI, Haodong; US
  • ADAMS, Mark, D.; US
Agents
  • OLSTEIN, Elliot, M.; Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein 6 Becker Farm Road Roseland, NJ 07068 , US
Priority Data
08/294,25123.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HUMAN CHEMOKINE BETA-9
(FR) CHEMOKINE BETA 9 HUMAINE
Abstract
(EN)
Human Ck$g(b)-9 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ck$g(b)-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune diseases, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic agent to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ck$g(b)-9 coding sequence and over-expression of the Ck$g(b)-9 protein.
(FR)
Polypeptides de type chémokine bêta 9 (Ck$g(b)-9) humaine et ADN (ARN) codant lesdits polypeptides, ainsi que procédé de production desdits polypeptides par des techniques de recombinaison. Des procédés d'utilisation desdits polypeptides Ck$g(b)-9 dans le traitement de la leucémie, des tumeurs, des infections chroniques, des maladies auto-immunes, des fibroses, de la cicatrisation et du psoriasis sont également décrits. Des antagonistes desdits polypeptides et leur utilisation en tant qu'agents thérapeutiques pour traiter la polyarthrite chronique évolutive, les inflammations auto-immunes et chroniques et les maladies infectieuses, les réactions allergiques, la fièvre indépendante des prostaglandines et l'insuffisance médullaire sont encore décrits. La présente invention concerne en outre des analyses diagnostiques permettant de détecter la présence de mutations dans la séquence de codage de Ck$g(b)-9 et la surexpression de la protéine Ck$g(b)-9.
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