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1. WO1996006166 - IMPROVEMENTS IN OR RELATING TO BINDING PROTEINS FOR RECOGNITION OF DNA

Publication Number WO/1996/006166
Publication Date 29.02.1996
International Application No. PCT/GB1995/001949
International Filing Date 17.08.1995
Chapter 2 Demand Filed 29.01.1996
IPC
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C12N 15/10 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C07K 14/4702
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4702Regulators; Modulating activity
C07K 14/4705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4702Regulators; Modulating activity
4705stimulating, promoting or activating activity
C07K 19/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
C07K 2319/09
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
01containing a localisation/targetting motif
09containing a nuclear localisation signal
C07K 2319/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Applicants
  • MEDICAL RESEARCH COUNCIL [GB/GB]; 20 Park Crescent London W1N 4AL, GB (AllExceptUS)
  • CHOO, Yen [SG/SG]; SG (UsOnly)
  • KLUG, Aaron [GB/GB]; GB (UsOnly)
  • SANCHEZ-GARCIA, Isidro [ES/ES]; ES (UsOnly)
Inventors
  • CHOO, Yen; SG
  • KLUG, Aaron; GB
  • SANCHEZ-GARCIA, Isidro; ES
Agents
  • KEITH W. NASH & CO.; Pearl Assurance House 90-92 Regent Street Cambridge CB2 1DP, GB
Priority Data
9416880.420.08.1994GB
9422534.908.11.1994GB
9514698.118.07.1995GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMPROVEMENTS IN OR RELATING TO BINDING PROTEINS FOR RECOGNITION OF DNA
(FR) AMELIORATIONS CONCERNANT DES PROTEINES DE LIAISON PERMETTANT DE RECONNAITRE L'ADN
Abstract
(EN)
Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a particular target sequence and, inter alia, use of designed zinc finger polypeptides for various $i(in vitro) or $i(in vivo) applications.
(FR)
On décrit des banques de séquences d'ADN qui codent des motifs de liaison en doigt de zinc destinés à être fixés sur une particule, des procédés de conception de polypeptides de liaison en doigt de zinc destinés à se lier à une séquence cible particulière et, notamment, l'utilisation de polypeptides en doigt de zinc déterminés concernant différentes applications $i(in vitro) ou $i(in vivo).
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