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1. WO1996006113 - NEW IMMUNOCONTRACEPTIVE PEPTIDES

Publication Number WO/1996/006113
Publication Date 29.02.1996
International Application No. PCT/EP1995/003311
International Filing Date 18.08.1995
Chapter 2 Demand Filed 29.01.1996
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
CPC
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
Applicants
  • AKZO NOBEL N.V. [NL/NL]; Velperweg 76 NL-6824 BM Arnhem, NL (AllExceptUS)
  • VAN DUIN, Marcel [NL/NL]; NL (UsOnly)
  • GROOTENHUIS, Arij, Jan [NL/NL]; NL (UsOnly)
  • BUNSCHOTEN, Evert, Johannes [NL/NL]; NL (UsOnly)
Inventors
  • VAN DUIN, Marcel; NL
  • GROOTENHUIS, Arij, Jan; NL
  • BUNSCHOTEN, Evert, Johannes; NL
Agents
  • BEETZ, T.; Postbus 20 NL-5340 BH Oss, NL
Priority Data
94202392.022.08.1994EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NEW IMMUNOCONTRACEPTIVE PEPTIDES
(FR) NOUVEAUX PEPTIDES IMMUNO-CONTRACEPTIFS
Abstract
(EN)
The present invention relates to a peptide capable of inducing an immune response against the Zona Pellucida protein ZP3, said peptide having an amino acid sequence of 8-50 amino acid residues and comprising at least the amino acid sequence PLWLLQ or analogues thereof. More specifically, the peptides according to the invention comprise at least the amino acid sequence QPLWLLQG. Further embodiments of the invention relate to antibodies raised against the peptides according to the invention, contraceptive vaccines comprising said peptides or said antibodies, as well as a test kit for the detection of autoimmune antibodies against ZP3 in a test sample.
(FR)
L'invention concerne un peptide susceptible d'induire une réponse immune contre la protéine ZP3 de la zone pellucide, ce peptide possédant une séquence d'acides aminés comprenant 8 à 50 restes d'acides aminés ainsi qu'au moins la séquence PLWLLQ ou des analogues de celle-ci. Plus particulièrement, les peptides selon l'invention comprennent au moins la séquence d'acides aminés QPLWLLQG. On décrit encore des anticorps dirigés contre les peptides selon l'invention, des vaccins contraceptifs comprenant ces peptides ou ces anticorps, ainsi qu'un nécessaire d'essai destiné à la détection des anticorps auto-immuns dirigés contre la protéine ZP3 dans un échantillon d'essai.
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