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1. WO1996006108 - CYCLIC CS-1 PEPTIDOMIMETICS, COMPOSITIONS AND METHODS OF USING THE SAME

Publication Number WO/1996/006108
Publication Date 29.02.1996
International Application No. PCT/US1995/010811
International Filing Date 25.08.1995
Chapter 2 Demand Filed 22.03.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/083 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
083the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/103 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
10Tetrapeptides
103the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/117 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
10Tetrapeptides
117the first amino acid being heterocyclic, e.g. Pro, His, Trp
C07K 5/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
12Cyclic peptides
C07K 14/78 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/78
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
C07K 5/0808
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
0802with the first amino acid being neutral
0804and aliphatic
0808the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
C07K 5/1013
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
10Tetrapeptides
1002with the first amino acid being neutral
1005and aliphatic
1013the side chain containing O or S as heteroatoms, e.g. Cys, Ser
C07K 5/1024
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
10Tetrapeptides
1024with the first amino acid being heterocyclic
C07K 5/126
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
12Cyclic peptides ; with only normal peptide bonds in the ring
126Tetrapeptides
Applicants
  • CYTEL CORPORATION [US/US]; 3525 John Hopkins Court San Diego, CA 92121, US
Inventors
  • ARRHENIUS, Thomas, S.; US
  • ELICES, Mariano, J.; US
  • TEMPCZYK, Anna; US
  • ZHENG, Zhong-Li; US
Agents
  • HOOK, Gregory, R. ; Campbell and Flores Suite 700 4370 La Jolla Village Drive San Diego, CA 92122, US
  • UEXKÜLL & STOLBERG; Beselerstrasse 4 D-22607 Hamburg, DE
Priority Data
08/296,24125.08.1994US
08/483,07707.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CYCLIC CS-1 PEPTIDOMIMETICS, COMPOSITIONS AND METHODS OF USING THE SAME
(FR) COMPOSES PEPTIDOMIMETIQUES CS-1 CYCLIQUES, COMPOSITIONS ET LEURS PROCEDES D'UTILISATION
Abstract
(EN)
The present invention contemplates a cyclic peptide that inhibits the binding between the VLA-4 receptor expressed on inflammatory leukocytes and the fibronectin CS-1 peptide expressed on endothelial cells that are involved in immunoinflammatory disease states. Pharmaceutical compositions containing a contemplated cyclic peptide and processes for treating immunoinflammatory conditions using a binding-inhibitory cyclic peptide are also disclosed.
(FR)
La présente invention concerne un peptide cyclique qui inhibe la liaison entre le récepteur VLA-4 exprimé sur les leucocytes inflammatoires et le peptide CS-1 de la fibronectine exprimé sur les cellules endothéliales qui interviennent dans les états pathologiques immuno-inflammatoires. Des compositions pharmaceutiques renfermant un peptide cyclique considéré et des procédés de traitement d'états immuno-inflammatoires mettant en ÷uvre un tel peptide cyclique inhibiteur de liaison sont également décrits.
Also published as
Latest bibliographic data on file with the International Bureau